Zygote intrafallopian transfer among patients with repeated implantation failure

Ariel Weissman*, Eran Horowitz, Amir Ravhon, Hana Nahum, Abraham Golan, David Levran

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: To summarize the experience of a single center with laparoscopic zygote intrafallopian transfer (ZIFT) performed exclusively among patients with high-order repeated implantation failure (RIF) following in vitro fertilization-embryo transfer (IVF-ET). Methods: A retrospective cohort study was performed at the Edith Wolfson Medical Center, a tertiary referral university hospital located in Holon, Israel. A group of 176 patients with 8.15 ± 3.9 previously failed IVF-ET cycles underwent 280 ZIFT procedures between 1995 and 2010. The main outcome measure was the live birth rate per patient treated. Results: In all, there were 274 fresh and 6 frozen ZIFT cycles recorded in the study cohort, resulting in 96 clinical pregnancies per attempt (34.3%) and 72 live births (25.7%). The live birth rate per patient was 39.8%. Conclusion: The use of ZIFT remains a powerful tool in the clinical management of selected patients with high-order RIF. This procedure should be kept in mind when all other measures fail among patients with at least 1 unobstructed fallopian tube.

Original languageEnglish
Pages (from-to)70-73
Number of pages4
JournalInternational Journal of Gynecology and Obstetrics
Issue number1
StatePublished - Jan 2013


  • In vitro fertilization-embryo transfer
  • Repeated implantation failure
  • Zygote intrafallopian transfer


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