TY - JOUR
T1 - Zwitterionic BODIPYs with large stokes shift
T2 - small molecular biomarkers for live cells
AU - Sekhar, Adiki Raja
AU - Sariki, Santhosh Kumar
AU - Reddy, R. V.Ramana
AU - Bisai, Alakesh
AU - Sahu, Pushpendra Kumar
AU - Tomar, Raghuvir S.
AU - Sankar, Jeyaraman
N1 - Publisher Copyright:
© The Royal Society of Chemistry.
PY - 2017
Y1 - 2017
N2 - The two first examples of zwitterionic BODIPYs have been synthesized via a simple SN-Ar methodology. The molecules exhibit excellent optical behavior, such as a large Stokes shift in solution and therefore a very intense emission, and can thus avoid self-quenching. The zwitterionic nature of the molecules was unambiguously elucidated using single crystal XRD studies. The electronic conjugation was investigated by NMR, DFT (NICS (0)) and XRD analysis. Due to their inherent ionic nature, their enhanced solubility in aqueous conditions was exploited for their utility in bio-imaging and cell viability studies. These molecules demonstrate promising localization inside live yeast cells.
AB - The two first examples of zwitterionic BODIPYs have been synthesized via a simple SN-Ar methodology. The molecules exhibit excellent optical behavior, such as a large Stokes shift in solution and therefore a very intense emission, and can thus avoid self-quenching. The zwitterionic nature of the molecules was unambiguously elucidated using single crystal XRD studies. The electronic conjugation was investigated by NMR, DFT (NICS (0)) and XRD analysis. Due to their inherent ionic nature, their enhanced solubility in aqueous conditions was exploited for their utility in bio-imaging and cell viability studies. These molecules demonstrate promising localization inside live yeast cells.
UR - http://www.scopus.com/inward/record.url?scp=85010430754&partnerID=8YFLogxK
U2 - 10.1039/c6cc09325f
DO - 10.1039/c6cc09325f
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C2 - 28054075
AN - SCOPUS:85010430754
SN - 1359-7345
VL - 53
SP - 1096
EP - 1099
JO - Chemical Communications
JF - Chemical Communications
IS - 6
ER -