Young-age onset of colorectal cancer in Israel

D. Neufeld, B. Shpitz, N. Bugaev, M. Grankin, J. Bernheim, E. Klein, Y. Ziv

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: The study was conducted to investigate the differences in clinical-pathological, ethnic, and demographic presentations and the expression of mismatch repair proteins in a cohort of young-onset (≤50 years) versus late-onset Israeli patients (>50 years) with colorectal cancer. Materials and methods: Clinical, demographic, and histopathological data of patients with colorectal cancer were collected retrospectively from medical records and pathology reports. Results: Ninety patients, 50 years of age or younger with a mean age of 42 years were compared with a group of 190 patients above 50 years of 50 (see Table 1). Sixty percent of the young-onset patients were females, compared to 40% in the older age group (P = 0.02). Twenty-one percent of the young-onset patients were Arabs as compared to 2% of older-onset patients (P = 0.001). Younger patients displayed a higher percentage of mucinous cancers and a higher percentage of diagnosis at an advanced stage of disease; 40% of young-onset versus 31% of older-onset patients presented Duke's stages C and D (P = 0.02). Conclusions: Younger age of onset colorectal cancer in our cohort of Israeli patients is associated with higher percentage of Arab patients, mucinous cancers, female gender, and advanced stage at diagnosis.

Original languageEnglish
Pages (from-to)201-204
Number of pages4
JournalTechniques in Coloproctology
Volume13
Issue number3
DOIs
StatePublished - Sep 2009
Externally publishedYes

Keywords

  • Colorectal cancer
  • Mucinous cancers
  • Young-onset colorectal cancers

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