Yield of bronchoalveolar lavage in ventilated and non-ventilated children after bone marrow transplantation

J. Ben-Ari*, I. Yaniv, E. Nahum, J. Stein, Z. Samra, T. Schonfeld

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

A study was undertaken to retrospectively evaluate the yield of bronchoalveolar lavage (BAL) in a single-institution series of children after bone marrow transplantation (BMT) and to compare the yield of BAL between the ventilated and nonventilated patients. We reviewed charts of 52 consecutive children after BMT who underwent BAL. Thirty patients (41 BALs) were non-ventilated (group 1) and 33 patients (45 BALs) were ventilated for respiratory failure (group 2). Eleven patients were included in both groups. BAL was performed a median of 255 and 28.5 days after BMT in groups 1 and 2, respectively (P<0.001). Group 1: 17 pathogens were isolated from 13 BALs; a single pathogens from 10 BALs. Group 2: 15 pathogens were isolated from 14 BALs (31.1% positive). Viruses were isolated from 13 BALs in group 2. A severe complication of BAL occurred in only one patient from group 1 (1.1%). Open lung biopsies were performed in one patient in group 1 and eight patients in group 2. The histological findings correlated with the BAL findings in 66.7%. In conclusion, there was no difference in the yield of BAL between the groups. Therapy was changed in one third of the patients dictated by the BAL findings. The risk of severe complications was relatively low. A good correlation between open lung biopsy (OLB) and BAL was found.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalBone Marrow Transplantation
Volume27
Issue number2
DOIs
StatePublished - 2001

Keywords

  • Bone marrow transplantation
  • Bronchoalveolar lavage
  • Mechanical ventilation
  • Pediatric intensive care unit
  • Respiratory failure

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