YbeY, a heat shock protein involved in translation in Escherichia col

Aviram Rasouly, Miriam Schonbrun, Yotam Shenhar, Eliora Z. Ron

Research output: Contribution to journalArticlepeer-review


Here we provide evidence that YbeY, a conserved heat shock protein with unknown function, is involved in the translation process. ybeY deletion mutants are temperature sensitive and have a significantly reduced thermotolerance. Nonetheless, there appears to be no damage of the protein quality control of mature polypeptides, as the levels of chaperones and proteases are normal and there is no accumulation of aggregates. Rather, the mutation results in a significant reduction in the level of polysomes, and upon a shift to a restrictive temperature (42°C), there is an immediate and severe slowdown of translation. Taken together, the data indicate that YbeY is an important factor for bacterial translation even at 37°C but becomes essential at high temperatures.

Original languageEnglish
Pages (from-to)2649-2655
Number of pages7
JournalJournal of Bacteriology
Issue number8
StatePublished - Apr 2009


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