Y chromosome sequence variation and the history of human populations

Peter A. Underhill; Peidong Shen; Alice A. Lin; Li Jin; Giuseppe Passarino; Wei H. Yang; Erin Kauffman; Batsheva Bonné-Tamir; Jaume Bertranpetit; Paolo Francalacci; Muntaser Ibrahim; Trefor Jenkins; Judith R. Kidd; S. Qasim Mehdi; Mark T. Seielstad; R. Spencer Wells; Alberto Piazza; Ronald W. Davis; Marcus W. Feldman; L. Luca Cavalli-Sforza; Peter J. Oefner

doi:10.1038/81685

Y chromosome sequence variation and the history of human populations

Peter A. Underhill^*, Peidong Shen, Alice A. Lin, Li Jin, Giuseppe Passarino, Wei H. Yang, Erin Kauffman, Batsheva Bonné-Tamir, Jaume Bertranpetit, Paolo Francalacci, Muntaser Ibrahim, Trefor Jenkins, Judith R. Kidd, S. Qasim Mehdi, Mark T. Seielstad, R. Spencer Wells, Alberto Piazza, Ronald W. Davis, Marcus W. Feldman, L. Luca Cavalli-SforzaPeter J. Oefner

^*Corresponding author for this work

Human Molecular Genetics Biochemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic legacy of our species that has persisted to the present, permitting inference of human evolution, population affinity and demographic history¹. We used denaturing high-performance liquid chromatography (DHPLC; ref. 2) to identify 160 of the 166 bi-allelic and 1 tri-allelic site that formed a parsimonious genealogy of 116 haplotypes, several of which display distinct population affinities based on the analysis of 1062 globally representative individuals. A minority of contemporary East Africans and Khoisan represent the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa between 35,000 and 89,000 years ago.

Original language	English
Pages (from-to)	358-361
Number of pages	4
Journal	Nature Genetics
Volume	26
Issue number	3
DOIs	https://doi.org/10.1038/81685
State	Published - 2000

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Underhill, P. A., Shen, P., Lin, A. A., Jin, L., Passarino, G., Yang, W. H., Kauffman, E., Bonné-Tamir, B., Bertranpetit, J., Francalacci, P., Ibrahim, M., Jenkins, T., Kidd, J. R., Mehdi, S. Q., Seielstad, M. T., Wells, R. S., Piazza, A., Davis, R. W., Feldman, M. W., ... Oefner, P. J. (2000). Y chromosome sequence variation and the history of human populations. Nature Genetics, 26(3), 358-361. https://doi.org/10.1038/81685

@article{4bd291e4322444dcabd18bf2c98e370c,

title = "Y chromosome sequence variation and the history of human populations",

abstract = "Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic legacy of our species that has persisted to the present, permitting inference of human evolution, population affinity and demographic history1. We used denaturing high-performance liquid chromatography (DHPLC; ref. 2) to identify 160 of the 166 bi-allelic and 1 tri-allelic site that formed a parsimonious genealogy of 116 haplotypes, several of which display distinct population affinities based on the analysis of 1062 globally representative individuals. A minority of contemporary East Africans and Khoisan represent the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa between 35,000 and 89,000 years ago.",

author = "Underhill, {Peter A.} and Peidong Shen and Lin, {Alice A.} and Li Jin and Giuseppe Passarino and Yang, {Wei H.} and Erin Kauffman and Batsheva Bonn{\'e}-Tamir and Jaume Bertranpetit and Paolo Francalacci and Muntaser Ibrahim and Trefor Jenkins and Kidd, {Judith R.} and Mehdi, {S. Qasim} and Seielstad, {Mark T.} and Wells, {R. Spencer} and Alberto Piazza and Davis, {Ronald W.} and Feldman, {Marcus W.} and Cavalli-Sforza, {L. Luca} and Oefner, {Peter J.}",

note = "Funding Information: We thank the 1,062 men who donated DNA; R.G. Klein, J. Mountain and M. Ruhlen for helpful discussions; D. Vollrath, R. Hyman and F.S. Dietrich for Y-specific cosmid sequences; and J. Block, D. Soergel, K. Prince, C. Edmonds and A. Rojas for technical help. A.W. Bergen made the RPS4YC711T marker (M130) information available to us before its publication. This work was supported in part by the NIH, NIHGR and L.S.B. Leakey Foundation.",

year = "2000",

doi = "10.1038/81685",

language = "אנגלית",

volume = "26",

pages = "358--361",

journal = "Nature Genetics",

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Underhill, PA, Shen, P, Lin, AA, Jin, L, Passarino, G, Yang, WH, Kauffman, E, Bonné-Tamir, B, Bertranpetit, J, Francalacci, P, Ibrahim, M, Jenkins, T, Kidd, JR, Mehdi, SQ, Seielstad, MT, Wells, RS, Piazza, A, Davis, RW, Feldman, MW, Cavalli-Sforza, LL & Oefner, PJ 2000, 'Y chromosome sequence variation and the history of human populations', Nature Genetics, vol. 26, no. 3, pp. 358-361. https://doi.org/10.1038/81685

TY - JOUR

T1 - Y chromosome sequence variation and the history of human populations

AU - Underhill, Peter A.

AU - Shen, Peidong

AU - Lin, Alice A.

AU - Jin, Li

AU - Passarino, Giuseppe

AU - Yang, Wei H.

AU - Kauffman, Erin

AU - Bonné-Tamir, Batsheva

AU - Bertranpetit, Jaume

AU - Francalacci, Paolo

AU - Ibrahim, Muntaser

AU - Jenkins, Trefor

AU - Kidd, Judith R.

AU - Mehdi, S. Qasim

AU - Seielstad, Mark T.

AU - Wells, R. Spencer

AU - Piazza, Alberto

AU - Davis, Ronald W.

AU - Feldman, Marcus W.

AU - Cavalli-Sforza, L. Luca

AU - Oefner, Peter J.

N1 - Funding Information: We thank the 1,062 men who donated DNA; R.G. Klein, J. Mountain and M. Ruhlen for helpful discussions; D. Vollrath, R. Hyman and F.S. Dietrich for Y-specific cosmid sequences; and J. Block, D. Soergel, K. Prince, C. Edmonds and A. Rojas for technical help. A.W. Bergen made the RPS4YC711T marker (M130) information available to us before its publication. This work was supported in part by the NIH, NIHGR and L.S.B. Leakey Foundation.

PY - 2000

Y1 - 2000

N2 - Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic legacy of our species that has persisted to the present, permitting inference of human evolution, population affinity and demographic history1. We used denaturing high-performance liquid chromatography (DHPLC; ref. 2) to identify 160 of the 166 bi-allelic and 1 tri-allelic site that formed a parsimonious genealogy of 116 haplotypes, several of which display distinct population affinities based on the analysis of 1062 globally representative individuals. A minority of contemporary East Africans and Khoisan represent the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa between 35,000 and 89,000 years ago.

AB - Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic legacy of our species that has persisted to the present, permitting inference of human evolution, population affinity and demographic history1. We used denaturing high-performance liquid chromatography (DHPLC; ref. 2) to identify 160 of the 166 bi-allelic and 1 tri-allelic site that formed a parsimonious genealogy of 116 haplotypes, several of which display distinct population affinities based on the analysis of 1062 globally representative individuals. A minority of contemporary East Africans and Khoisan represent the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa between 35,000 and 89,000 years ago.

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VL - 26

SP - 358

EP - 361

JO - Nature Genetics

JF - Nature Genetics

IS - 3

ER -

Y chromosome sequence variation and the history of human populations

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