Work in progress: ultrasonic texture of normal rat liver tissue using a standardized in vivo measurement.

G. Horev, R. R. Price, J. J. Erickson, A. C. Fleischer, A. E. James

Research output: Contribution to journalArticlepeer-review

Abstract

A prototype computer-augmented diagnostic ultrasound system was used in an investigation of the range of echo amplitudes obtained from measurements of normal exteriorized rat livers. A secondary goal was to develop a method for minimizing variations in measurement techniques and instrument stability. The average echo amplitude was obtained from a user-selected homogeneous region of the liver on a B-mode scan image. A similar B-mode scan of a commercially available liver tissue equivalent phantom was also obtained immediately after each rat liver measurement and was used as a calibration scan. A normalization factor developed from the calibration scan was used to correct all in vivo measurements for system variation. The average echo amplitude from the livers of a group of normal rats, when corrected by the calibration scan, exhibited a narrow range of values with a coefficient of variation of only 5%. The development of a technique that yields a narrow range of values for normal tissues should encourage further investigation of tissue characterization methods.

Original languageEnglish
Pages (from-to)773-775
Number of pages3
JournalRadiology
Volume145
Issue number3
DOIs
StatePublished - Dec 1982

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