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Within-individual variability in cognitive performance in schizophrenia: A narrative review of the key literature and proposed research agenda

  • Olivia Wootton*
  • , Shareefa Dalvie
  • , Ezra Susser
  • , Ruben C. Gur
  • , Dan J. Stein
  • *Corresponding author for this work
  • University of Cape Town
  • South African Medical Research Council
  • Columbia University
  • University of Pennsylvania
  • SA MRC Unit on Risk and Resilience in Mental Disorders

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Schizophrenia is a neurodevelopmental disorder and a leading cause of disability worldwide. Deficits in cognitive function are characteristic of schizophrenia and are predictors of functional outcomes in the disorder. Within-individual variability (WIV) in cognitive performance is elevated in schizophrenia and has been suggested to provide additional insight into cognitive function over and above mean performance measures. Despite growing interest in WIV in schizophrenia, research on the clinical significance and neural correlates of WIV in the disorder remains sparse. The present narrative review summarizes the key literature linking WIV in schizophrenia to clinical, neural, and genetic correlates. Here, we aim to highlight key knowledge gaps and provide directions for future research into WIV in schizophrenia.

Original languageEnglish
Pages (from-to)329-334
Number of pages6
JournalSchizophrenia Research
Volume252
DOIs
StatePublished - Feb 2023
Externally publishedYes

Funding

FundersFunder number
National Institute of Mental HealthU01MH125053

    Keywords

    • Cognition
    • Genetic predisposition to disease
    • Neuroimaging
    • Reaction time
    • Schizophrenia
    • Within-individual variability

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