Will in vitro maturation ever be used in all IVF patients?

Ezgi Demirtas, Hananel Holzer, Weon Young Son, Shai Elizur, Dan Levin, Ri Cheng Chian, Seang Lin Tan

Research output: Contribution to journalReview articlepeer-review


In vitro maturation of human oocytes obtained from unstimulated ovaries offers a more 'patient friendly' treatment option than conventional IVF treatment with ovarian stimulation to the couples undergoing assisted reproductive technologies. It has classically been offered to women who are considered high risk for ovarian hyperstimulation syndrome. Since significant progress has been made to improve the implantation and pregnancy rates using in vitro matured oocytes, the patient spectrum for in vitro maturation treatment has become wider. However, implantation and pregnancy rates of conventional IVF are still higher than those of unstimulated cycles followed by in vitro maturation. To improve the in vitro maturation outcomes, some studies have focused on improving in vitro culture conditions, whereas others have tried to improve the quality and quantity of oocytes retrieved by modifications in the follow-up of treatment cycles.

Original languageEnglish
Pages (from-to)627-634
Number of pages8
JournalExpert Review of Obstetrics and Gynecology
Issue number5
StatePublished - Sep 2008
Externally publishedYes


  • IVF
  • In vitro maturation
  • Oocyte
  • Ovarian hyperstimulation syndrome


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