Wild emmer genome architecture and diversity elucidate wheat evolution and domestication

Raz Avni; Moran Nave; Omer Barad; Kobi Baruch; Sven O. Twardziok; Heidrun Gundlach; Iago Hale; Martin Mascher; Manuel Spannagl; Krystalee Wiebe; Katherine W. Jordan; Guy Golan; Jasline Deek; Batsheva Ben-Zvi; Gil Ben-Zvi; Axel Himmelbach; Ron P. Maclachlan; Andrew G. Sharpe; Allan Fritz; Roi Ben-David; Hikmet Budak; Tzion Fahima; Abraham Korol; Justin D. Faris; Alvaro Hernandez; Mark A. Mikel; Avraham A. Levy; Brian Steffenson; Marco Maccaferri; Roberto Tuberosa; Luigi Cattivelli; Primetta Faccioli; Aldo Ceriotti; Khalil Kashkush; Mohammad Pourkheirandish; Takao Komatsuda; Tamar Eilam; Hanan Sela; Amir Sharon; Nir Ohad; Daniel A. Chamovitz; Klaus F.X. Mayer; Nils Stein; Gil Ronen; Zvi Peleg; Curtis J. Pozniak; Eduard D. Akhunov; Assaf Distelfeld

doi:10.1126/science.aan0032

Wild emmer genome architecture and diversity elucidate wheat evolution and domestication

Raz Avni
, Moran Nave
, Omer Barad
, Kobi Baruch
, Sven O. Twardziok
, Heidrun Gundlach
, Iago Hale
, Martin Mascher
, Manuel Spannagl
, Krystalee Wiebe
, Katherine W. Jordan
, Guy Golan
, Jasline Deek
, Batsheva Ben-Zvi
, Gil Ben-Zvi
, Axel Himmelbach
, Ron P. Maclachlan
, Andrew G. Sharpe
, Allan Fritz
, Roi Ben-David

Hikmet Budak, Tzion Fahima, Abraham Korol, Justin D. Faris, Alvaro Hernandez, Mark A. Mikel, Avraham A. Levy, Brian Steffenson, Marco Maccaferri, Roberto Tuberosa, Luigi Cattivelli, Primetta Faccioli, Aldo Ceriotti, Khalil Kashkush, Mohammad Pourkheirandish, Takao Komatsuda, Tamar Eilam, Hanan Sela, Amir Sharon, Nir Ohad, Daniel A. Chamovitz, Klaus F.X. Mayer, Nils Stein, Gil Ronen, Zvi Peleg, Curtis J. Pozniak, Eduard D. Akhunov, Assaf Distelfeld^*

^*Corresponding author for this work

School of Plant Sciences and Food Security

NRGENE
Helmholtz Zentrum München - German Research Center for Environmental Health
University of New Hampshire
Leibniz Institute of Plant Genetics and Crop Plant Research
German Center for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig
University of Saskatchewan
Kansas State University
Hebrew University of Jerusalem
Tel Aviv University
Agricultural Research Organization of Israel
Montana State University
University of Haifa
United States Department of Agriculture
University of Illinois at Urbana-Champaign
Weizmann Institute of Science
University of Minnesota Twin Cities
University of Bologna
Council of Agricultural Research and Economics–Research Centre for Genomics and Bioinformatics
National Research Council of Italy
Ben-Gurion University of the Negev
National Agriculture and Food Research Organization
Technical University of Munich

Research output: Contribution to journal › Article › peer-review

666 Scopus citations

Abstract

Wheat (Triticum spp.) is one of the founder crops that likely drove the Neolithic transition to sedentary agrarian societies in the Fertile Crescent more than 10,000 years ago. Identifying genetic modifications underlying wheat’s domestication requires knowledge about the genome of its allo-tetraploid progenitor, wild emmer (T. turgidum ssp. dicoccoides).We report a 10.1-gigabase assembly of the 14 chromosomes of wild tetraploid wheat, as well as analyses of gene content, genome architecture, and genetic diversity. With this fully assembled polyploid wheat genome, we identified the causal mutations in Brittle Rachis 1 (TtBtr1) genes controlling shattering, a key domestication trait. A study of genomic diversity among wild and domesticated accessions revealed genomic regions bearing the signature of selection under domestication. This reference assembly will serve as a resource for accelerating the genome-assisted improvement of modern wheat varieties.

Original language	English
Pages (from-to)	93-97
Number of pages	5
Journal	Science
Volume	357
Issue number	6346
DOIs	https://doi.org/10.1126/science.aan0032
State	Published - 7 Jul 2017

Funding

Funders	Funder number
Italian Ministry of Education and Research Flagship InterOmics	PB05
Saskashewan Ministry of Agriculture and Western Grains Research Foundation
U.S. Agency for International Development Middle East Research and Cooperation	M34-037
USDA NIFA
National Institute of Food and Agriculture	2016-67013-24473
University of Minnesota	LSYQ00000000
Genome Canada
German-Israeli Foundation for Scientific Research and Development	I-1212-315.13
United States-Israel Binational Science Foundation	2015409, 2013396
Bundesministerium für Bildung und Forschung	031A536, 0314000, 0315954
Israel Science Foundation	999/12, 1824/12, 322/15
Tel Aviv University
Genome Prairie

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 2 Zero Hunger

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10.1126/science.aan0032

Cite this

Avni, R., Nave, M., Barad, O., Baruch, K., Twardziok, S. O., Gundlach, H., Hale, I., Mascher, M., Spannagl, M., Wiebe, K., Jordan, K. W., Golan, G., Deek, J., Ben-Zvi, B., Ben-Zvi, G., Himmelbach, A., Maclachlan, R. P., Sharpe, A. G., Fritz, A., ... Distelfeld, A. (2017). Wild emmer genome architecture and diversity elucidate wheat evolution and domestication. Science, 357(6346), 93-97. https://doi.org/10.1126/science.aan0032

@article{c702043e33934001bf70eb1e9df09007,

title = "Wild emmer genome architecture and diversity elucidate wheat evolution and domestication",

abstract = "Wheat (Triticum spp.) is one of the founder crops that likely drove the Neolithic transition to sedentary agrarian societies in the Fertile Crescent more than 10,000 years ago. Identifying genetic modifications underlying wheat{\textquoteright}s domestication requires knowledge about the genome of its allo-tetraploid progenitor, wild emmer (T. turgidum ssp. dicoccoides).We report a 10.1-gigabase assembly of the 14 chromosomes of wild tetraploid wheat, as well as analyses of gene content, genome architecture, and genetic diversity. With this fully assembled polyploid wheat genome, we identified the causal mutations in Brittle Rachis 1 (TtBtr1) genes controlling shattering, a key domestication trait. A study of genomic diversity among wild and domesticated accessions revealed genomic regions bearing the signature of selection under domestication. This reference assembly will serve as a resource for accelerating the genome-assisted improvement of modern wheat varieties.",

author = "Raz Avni and Moran Nave and Omer Barad and Kobi Baruch and Twardziok, \{Sven O.\} and Heidrun Gundlach and Iago Hale and Martin Mascher and Manuel Spannagl and Krystalee Wiebe and Jordan, \{Katherine W.\} and Guy Golan and Jasline Deek and Batsheva Ben-Zvi and Gil Ben-Zvi and Axel Himmelbach and Maclachlan, \{Ron P.\} and Sharpe, \{Andrew G.\} and Allan Fritz and Roi Ben-David and Hikmet Budak and Tzion Fahima and Abraham Korol and Faris, \{Justin D.\} and Alvaro Hernandez and Mikel, \{Mark A.\} and Levy, \{Avraham A.\} and Brian Steffenson and Marco Maccaferri and Roberto Tuberosa and Luigi Cattivelli and Primetta Faccioli and Aldo Ceriotti and Khalil Kashkush and Mohammad Pourkheirandish and Takao Komatsuda and Tamar Eilam and Hanan Sela and Amir Sharon and Nir Ohad and Chamovitz, \{Daniel A.\} and Mayer, \{Klaus F.X.\} and Nils Stein and Gil Ronen and Zvi Peleg and Pozniak, \{Curtis J.\} and Akhunov, \{Eduard D.\} and Assaf Distelfeld",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors, some rights reserved.",

year = "2017",

month = jul,

day = "7",

doi = "10.1126/science.aan0032",

language = "אנגלית",

volume = "357",

pages = "93--97",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6346",

}

Avni, R, Nave, M, Barad, O, Baruch, K, Twardziok, SO, Gundlach, H, Hale, I, Mascher, M, Spannagl, M, Wiebe, K, Jordan, KW, Golan, G, Deek, J, Ben-Zvi, B, Ben-Zvi, G, Himmelbach, A, Maclachlan, RP, Sharpe, AG, Fritz, A, Ben-David, R, Budak, H, Fahima, T, Korol, A, Faris, JD, Hernandez, A, Mikel, MA, Levy, AA, Steffenson, B, Maccaferri, M, Tuberosa, R, Cattivelli, L, Faccioli, P, Ceriotti, A, Kashkush, K, Pourkheirandish, M, Komatsuda, T, Eilam, T, Sela, H, Sharon, A , Ohad, N , Chamovitz, DA, Mayer, KFX, Stein, N, Ronen, G, Peleg, Z, Pozniak, CJ, Akhunov, ED & Distelfeld, A 2017, 'Wild emmer genome architecture and diversity elucidate wheat evolution and domestication', Science, vol. 357, no. 6346, pp. 93-97. https://doi.org/10.1126/science.aan0032

TY - JOUR

T1 - Wild emmer genome architecture and diversity elucidate wheat evolution and domestication

AU - Avni, Raz

AU - Nave, Moran

AU - Barad, Omer

AU - Baruch, Kobi

AU - Twardziok, Sven O.

AU - Gundlach, Heidrun

AU - Hale, Iago

AU - Mascher, Martin

AU - Spannagl, Manuel

AU - Wiebe, Krystalee

AU - Jordan, Katherine W.

AU - Golan, Guy

AU - Deek, Jasline

AU - Ben-Zvi, Batsheva

AU - Ben-Zvi, Gil

AU - Himmelbach, Axel

AU - Maclachlan, Ron P.

AU - Sharpe, Andrew G.

AU - Fritz, Allan

AU - Ben-David, Roi

AU - Budak, Hikmet

AU - Fahima, Tzion

AU - Korol, Abraham

AU - Faris, Justin D.

AU - Hernandez, Alvaro

AU - Mikel, Mark A.

AU - Levy, Avraham A.

AU - Steffenson, Brian

AU - Maccaferri, Marco

AU - Tuberosa, Roberto

AU - Cattivelli, Luigi

AU - Faccioli, Primetta

AU - Ceriotti, Aldo

AU - Kashkush, Khalil

AU - Pourkheirandish, Mohammad

AU - Komatsuda, Takao

AU - Eilam, Tamar

AU - Sela, Hanan

AU - Sharon, Amir

AU - Ohad, Nir

AU - Chamovitz, Daniel A.

AU - Mayer, Klaus F.X.

AU - Stein, Nils

AU - Ronen, Gil

AU - Peleg, Zvi

AU - Pozniak, Curtis J.

AU - Akhunov, Eduard D.

AU - Distelfeld, Assaf

PY - 2017/7/7

Y1 - 2017/7/7

N2 - Wheat (Triticum spp.) is one of the founder crops that likely drove the Neolithic transition to sedentary agrarian societies in the Fertile Crescent more than 10,000 years ago. Identifying genetic modifications underlying wheat’s domestication requires knowledge about the genome of its allo-tetraploid progenitor, wild emmer (T. turgidum ssp. dicoccoides).We report a 10.1-gigabase assembly of the 14 chromosomes of wild tetraploid wheat, as well as analyses of gene content, genome architecture, and genetic diversity. With this fully assembled polyploid wheat genome, we identified the causal mutations in Brittle Rachis 1 (TtBtr1) genes controlling shattering, a key domestication trait. A study of genomic diversity among wild and domesticated accessions revealed genomic regions bearing the signature of selection under domestication. This reference assembly will serve as a resource for accelerating the genome-assisted improvement of modern wheat varieties.

AB - Wheat (Triticum spp.) is one of the founder crops that likely drove the Neolithic transition to sedentary agrarian societies in the Fertile Crescent more than 10,000 years ago. Identifying genetic modifications underlying wheat’s domestication requires knowledge about the genome of its allo-tetraploid progenitor, wild emmer (T. turgidum ssp. dicoccoides).We report a 10.1-gigabase assembly of the 14 chromosomes of wild tetraploid wheat, as well as analyses of gene content, genome architecture, and genetic diversity. With this fully assembled polyploid wheat genome, we identified the causal mutations in Brittle Rachis 1 (TtBtr1) genes controlling shattering, a key domestication trait. A study of genomic diversity among wild and domesticated accessions revealed genomic regions bearing the signature of selection under domestication. This reference assembly will serve as a resource for accelerating the genome-assisted improvement of modern wheat varieties.

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U2 - 10.1126/science.aan0032

DO - 10.1126/science.aan0032

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C2 - 28684525

AN - SCOPUS:85024404293

SN - 0036-8075

VL - 357

SP - 93

EP - 97

JO - Science

JF - Science

IS - 6346

ER -

Wild emmer genome architecture and diversity elucidate wheat evolution and domestication

Abstract

Funding

UN SDGs

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