Who will remain tremor dominant? The possible role of cognitive reserve in the time course of two common Parkinson’s disease motor subtypes

Talia Herman*, S. Shema-Shiratzky, L. Arie, N. Giladi, J. M. Hausdorff

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

In a prospective 5-year study among Parkinson’s disease (PD) tremor-dominant (TD) patients, we investigated who will remain TD and who will later convert into the postural instability gait difficulty (PIGD) phenotype. At follow-up, 38% were still considered TD. At baseline the TD non-convertors had more years of education and better cognitive function than the convertors and significantly smaller deterioration in gait, balance, cognitive function and other non-motor symptoms. These results highlight the potential role of cognition in protecting against the development of PIGD symptoms.

Original languageEnglish
Pages (from-to)1007-1011
Number of pages5
JournalJournal of Neural Transmission
Volume125
Issue number6
DOIs
StatePublished - 1 Jun 2018

Funding

FundersFunder number
European Union 7th Framework Program and the Israel Science Foundation
LTI
TevaPharma2B
Teva NNE
Michael J. Fox Foundation for Parkinson's Research
National Parkinson Foundation
Pfizer
Biogen
AbbVie
International Parkinson and Movement Disorder Society
Seventh Framework Programme
UCB
Denali Commission
Israel Science Foundation

    Keywords

    • Cognitive function
    • Gait
    • PIGD
    • Parkinson’s disease
    • Tremor dominant

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