Which semen analysis correlates with favorable Intracytoplasmic morphologically selected sperm injection (IMSI) outcomes?

Natali Schachter-Safrai*, Gilad Karavani, Adi Reuveni-Salzman, Moran Gil, Assaf Ben-Meir

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To assess whether a correlation exists between different sperm pathologies and Intracytoplasmic morphologically selected sperm injection (IMSI) outcomes. Study design: A retrospective cohort study which included couples with recurrent implantation failures (2 or more unsuccessful IVF-ICSI cycles) undergoing their first IVF-IMSI cycle in Hebrew-University Hadassah Medical Center between January 2008 and May 2017. Results: A total of 170 couples with at least two IVF failures attempting their first IVF-IMSI cycle were included, of them 56 (32.9%) achieved a clinical pregnancy. No correlation was found between clinical pregnancy and a specific abnormal semen parameter. However, a positive correlation with clinical pregnancy was demonstrated when all three semen parameters were abnormal (OR-3.33, p = 0.015). Conclusions: Our findings suggest that IMSI procedure may be more efficient in severe compound sperm pathologies than in patients with one abnormal sperm parameter. Future prospective trials are required to reinforce these findings and allow formation of clear indications for IMSI.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume234
DOIs
StatePublished - Mar 2019
Externally publishedYes

Keywords

  • Intracytoplasmic morphologically selected sperm injection (IMSI)
  • Intracytoplasmic sperm injection (ICSI)
  • Oligoasthenoteratozoospermia (OAT)

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