Where can biology of childhood ALL be attacked by new compounds?

Jean Pierre Bourquin, Shai Izraeli

Research output: Contribution to journalReview articlepeer-review

Abstract

Although the majority of children with acute lymphoblastic leukemia (ALL) can be cured with combination chemotherapy, the challenge remains to salvage patients with resistant disease and to reduce treatment related toxicity. To meet this challenge, it will be essential to incorporate new agents targeting the biological Achilles Heels of this cancer more rapidly into currently available treatment regimen. Here we review the principles of current ALL therapy, recent advances in understanding ALL biology and discuss a selection of promising areas for drug development that may take advantage of the underlying leukemia biology. We focus particularly on strategies to interfere with common effector mechanisms that can be trigged by different individual oncogenic lesions and on new agents from drug development programs in adult oncology, as such agents will come with better chances for sustainable commercial development.

Original languageEnglish
Pages (from-to)298-306
Number of pages9
JournalCancer Treatment Reviews
Volume36
Issue number4
DOIs
StatePublished - Jun 2010
Externally publishedYes

Keywords

  • Acute lymphoblastic leukemia
  • AKT inhibitors
  • Apoptosis
  • Autophagy
  • BH3-mimetics
  • Chemosensitization
  • MTOR inhibitors
  • Targeted therapy

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