What's hot about otoferlin

Research output: Contribution to journalComment/debate


Mutations in the otoferlin (OTOF) gene lead to profound hearing loss in humans. Interestingly, a number of missense otoferlin mutations cause hearing defects but only at higher body temperature, and the reasons for this have been elusive until now. A study published in this issue of The EMBO Journal (Strenzke et al,) adds insight into the underlying mechanisms for this heat-dependent hearing loss.

Original languageEnglish
Pages (from-to)2502-2504
Number of pages3
JournalEMBO Journal
Issue number23
StatePublished - 1 Dec 2016


Dive into the research topics of 'What's hot about otoferlin'. Together they form a unique fingerprint.

Cite this