What's hot about otoferlin

Research output: Contribution to journalComment/debate

Abstract

Mutations in the otoferlin (OTOF) gene lead to profound hearing loss in humans. Interestingly, a number of missense otoferlin mutations cause hearing defects but only at higher body temperature, and the reasons for this have been elusive until now. A study published in this issue of The EMBO Journal (Strenzke et al,) adds insight into the underlying mechanisms for this heat-dependent hearing loss.

Original languageEnglish
Pages (from-to)2502-2504
Number of pages3
JournalEMBO Journal
Volume35
Issue number23
DOIs
StatePublished - 1 Dec 2016

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