What is the optimal threshold of serum Anti-Müllerian hormone (AMH) necessary for IVM treatments?

Alon Kedem, Gil M. Yerushalmi, Ettie Maman, Rina Hemi, Mirit Hanochi, Ariel Hourvitz

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To assesse circulating levels of Anti-Müllerian hormone (AMH) as a predictor of oocyte number and their potential to mature in vitro in both normo-ovulatory (NO) women and in women with Polycystic Ovary Syndrome (PCOS) undergoing in vitro maturation (IVM) treatments. Methods: We prospectively studied NO women and women diagnosed with PCOS, (age range 21-39 years) underwent IVM treatments at our center. Serum AMH levels were quantified before each cycle and correlated to oocytes number, maturation and fertilization during in vitro maturation. Results: 104 NO and 30 PCOS IVM cycles were followed with retrieval of a total of 672 and 491 oocytes, respectively. In NO women, the serum AMH level positively correlated with the number of oocytes retrieved, (R = 0.6; P <0.0001) the number of M2 oocytes at 24 and 48 h (R = 0.4; P <0.01; R = 0.26 p < 0.007, respectively) and with the total number of M2 oocytes (R = 0.47; P < 0.0001). In the PCOS group, the serum AMH level positively correlated only with the number of oocytes retrieved (R = 0.43; P <0.03). Receiver operating characteristic (ROC) analyses showed that a cutoff AMH level of 1.56 (ng/ml) could identify patients with 5 or more oocytes at OPU with a sensitivity of 83 % and a specificity of 75 %. An AMH level of 1.63 (ng/ml) was the threshold for 5 or more matured oocytes (sensitivity = 81 %, specificity = 53 %). Conclusions: Serum AMH may be used as a marker to identify candidates for IVM treatment in both NO and PCOS women.

Original languageEnglish
Pages (from-to)745-751
Number of pages7
JournalJournal of Assisted Reproduction and Genetics
Volume30
Issue number6
DOIs
StatePublished - Jun 2013

Keywords

  • Anti-Müllerian hormone
  • In vitro maturation
  • Oocyte maturation
  • PCOS

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