Abstract
Respiratory complaints and nonspecific systemic symptoms combined with bilateral ground glass opacities on chest imaging constitute the clinical and radiological picture of both COVID-19 disease and anti-MDA5 dermatomyositis. Those findings together with the identification of anti-MDA5 antibodies in sera of certain COVID-19-positive patients allude for a common immunogenic basis. The common pathophysiological denominator is the cytokine storm. Modulation of interferon beta pathway plays role in both diseases; this observation can direct us for potential immunomodulatory therapies for both COVID-19 and anti-MDA5 dermatomyositis. This chapter will discuss in detail the clinical, radiological, and laboratory similarities of both COVID-19 disease and anti-MDA5 dermatomyositis.
| Original language | English |
|---|---|
| Title of host publication | Autoimmunity, COVID-19, Post-COVID19 Syndrome and COVID-19 Vaccination |
| Publisher | Elsevier |
| Pages | 369-374 |
| Number of pages | 6 |
| ISBN (Electronic) | 9780443185663 |
| ISBN (Print) | 9780443185670 |
| DOIs | |
| State | Published - 1 Jan 2022 |
Keywords
- Anti-MDA5
- COVID-19 and autoimmunity
- Cytokine storm
- Dermatomyositis
- Interferon beta
