What do we know about dynamic glucose-enhanced (DGE) MRI and how close is it to the clinics? Horizon 2020 GLINT consortium report

the GLINT consortium

Research output: Contribution to journalReview articlepeer-review

Abstract

Cancer is one of the most devastating diseases that the world is currently facing, accounting for 10 million deaths in 2020 (WHO). In the last two decades, advanced medical imaging has played an ever more important role in the early detection of the disease, as it increases the chances of survival and the potential for full recovery. To date, dynamic glucose-enhanced (DGE) MRI using glucose-based chemical exchange saturation transfer (glucoCEST) has demonstrated the sensitivity to detect both d-glucose and glucose analogs, such as 3-oxy-methyl-d-glucose (3OMG) uptake in tumors. As one of the recent international efforts aiming at pushing the boundaries of translation of the DGE MRI technique into clinical practice, a multidisciplinary team of eight partners came together to form the “glucoCEST Imaging of Neoplastic Tumors (GLINT)” consortium, funded by the Horizon 2020 European Commission. This paper summarizes the progress made to date both by these groups and others in increasing our knowledge of the underlying mechanisms related to this technique as well as translating it into clinical practice.

Original languageEnglish
Pages (from-to)87-104
Number of pages18
JournalMagnetic Resonance Materials in Physics, Biology, and Medicine
Volume35
Issue number1
DOIs
StatePublished - Feb 2022

Funding

FundersFunder number
European Institute for Biomedical Imaging Research
Horizon 2020 Framework Programme667510
National Institute for Health and Care Research
UCLH Biomedical Research Centre

    Keywords

    • 3-Oxy-methyl-d-glucose
    • CEST
    • Cancer
    • DGE MRI
    • Glucose
    • MRI
    • glucoCEST

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