Wave of the future: involvement of actin polymerization in the regulation of tissue growth and shape

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Abstract

The WASP-family verprolin-homologous (Wave) complex enhances actin-related protein 2/3 (Arp2/3)-mediated actin polymerization. Recently, we have identified a novel Wave complex–actin–Wnt/β-catenin–Sox9 pathway that regulates epidermal morphogenesis and proliferation. These findings highlight a mechanism by which actin polymerization impacts crucial signaling events in vivo.

Original languageEnglish
Article numbere1609877
JournalMolecular and Cellular Oncology
Volume6
Issue number5
DOIs
StatePublished - 2019

Keywords

  • SOX9
  • Wave complex
  • Wnt
  • actin polymerization
  • epidermis

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