Wave of the future: involvement of actin polymerization in the regulation of tissue growth and shape

Jonathan Cohen, Chen Luxenburg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The WASP-family verprolin-homologous (Wave) complex enhances actin-related protein 2/3 (Arp2/3)-mediated actin polymerization. Recently, we have identified a novel Wave complex–actin–Wnt/β-catenin–Sox9 pathway that regulates epidermal morphogenesis and proliferation. These findings highlight a mechanism by which actin polymerization impacts crucial signaling events in vivo.

Original languageEnglish
Article numbere1609877
JournalMolecular and Cellular Oncology
Volume6
Issue number5
DOIs
StatePublished - 2019

Funding

FundersFunder number
Israel Science Foundation1113/15
Israeli Centers for Research Excellence41/11

    Keywords

    • SOX9
    • Wave complex
    • Wnt
    • actin polymerization
    • epidermis

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