Wave of the future: involvement of actin polymerization in the regulation of tissue growth and shape

Jonathan Cohen; Chen Luxenburg

doi:10.1080/23723556.2019.1609877

Wave of the future: involvement of actin polymerization in the regulation of tissue growth and shape

Research output: Contribution to journal › Article › peer-review

Abstract

The WASP-family verprolin-homologous (Wave) complex enhances actin-related protein 2/3 (Arp2/3)-mediated actin polymerization. Recently, we have identified a novel Wave complex–actin–Wnt/β-catenin–Sox9 pathway that regulates epidermal morphogenesis and proliferation. These findings highlight a mechanism by which actin polymerization impacts crucial signaling events in vivo.

Original language	English
Article number	e1609877
Journal	Molecular and Cellular Oncology
Volume	6
Issue number	5
DOIs	https://doi.org/10.1080/23723556.2019.1609877
State	Published - 2019

Keywords

SOX9
Wave complex
Wnt
actin polymerization
epidermis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2019.1609877

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title = "Wave of the future: involvement of actin polymerization in the regulation of tissue growth and shape",

abstract = "The WASP-family verprolin-homologous (Wave) complex enhances actin-related protein 2/3 (Arp2/3)-mediated actin polymerization. Recently, we have identified a novel Wave complex–actin–Wnt/β-catenin–Sox9 pathway that regulates epidermal morphogenesis and proliferation. These findings highlight a mechanism by which actin polymerization impacts crucial signaling events in vivo.",

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author = "Jonathan Cohen and Chen Luxenburg",

note = "Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 Taylor & Francis Group, LLC.",

year = "2019",

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AU - Luxenburg, Chen

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AB - The WASP-family verprolin-homologous (Wave) complex enhances actin-related protein 2/3 (Arp2/3)-mediated actin polymerization. Recently, we have identified a novel Wave complex–actin–Wnt/β-catenin–Sox9 pathway that regulates epidermal morphogenesis and proliferation. These findings highlight a mechanism by which actin polymerization impacts crucial signaling events in vivo.

KW - SOX9

KW - Wave complex

KW - Wnt

KW - actin polymerization

KW - epidermis

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DO - 10.1080/23723556.2019.1609877

M3 - מאמר

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JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

SN - 2372-3556

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ER -

Wave of the future: involvement of actin polymerization in the regulation of tissue growth and shape

Abstract

Keywords

UN SDGs

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