Waldenström's macroglobulinemia associated with AA amyloidosis

J. Gardyn, A. Schwartz, R. Gal, U. Lewinski, D. Kristt, A. M. Cohen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


It is widely accepted that amyloidosis in Waldenström's macroglobulinemia (WM) is exclusively due to amyloid light-chain deposition. However, only a small number of previous reports have actually characterized the type of amyloid in WM. We now report the third patient with WM and amyloid A protein (AA) amyloidosis. This patient developed malabsorption, nephrotic syndrome, and orthostatic hypotension. AA was immunohistochemically demonstrated in the rectal biopsy. In conjunction with previous examples of AA amyloidosis, the present report raises the possibility that AA amyloidosis may also occur in WM patients.

Original languageEnglish
Pages (from-to)76-78
Number of pages3
JournalInternational Journal of Hematology
Issue number1
StatePublished - 2001


  • Nephrotic syndrome
  • Secondary amyloidosis
  • Waldenström's macroglobulinemia


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