Waiting for ON: A major problem in patients with Parkinson disease and ON/OFF motor fluctuations

Doron Merims; Ruth Djaldetti; Eldad Melamed

doi:10.1097/00002826-200307000-00009

Waiting for ON: A major problem in patients with Parkinson disease and ON/OFF motor fluctuations

Doron Merims, Ruth Djaldetti, Eldad Melamed^*

^*Corresponding author for this work

Rabin Medical Center Israel

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The authors compared the two portions of the OFF period in patients with Parkinson disease and response fluctuations: time to ON (the latency from levodopa intake to turning ON) and wearing off (time from termination of the beneficial dose effect until the time when the next dose was taken). Time to ON was more than twice the duration of wearing off. Although underrecognized, time to ON is the major component of total daily OFF.

Original language	English
Pages (from-to)	196-198
Number of pages	3
Journal	Clinical Neuropharmacology
Volume	26
Issue number	4
DOIs	https://doi.org/10.1097/00002826-200307000-00009
State	Published - Jul 2003
Externally published	Yes

Keywords

Delayed ON
Fluctuations
Parkinson disease
Time to ON

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10.1097/00002826-200307000-00009

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Waiting for ON: A major problem in patients with Parkinson disease and ON/OFF motor fluctuations

Abstract

Keywords

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