TY - JOUR
T1 - Voriconazole-induced QT interval prolongation and ventricular tachycardia
T2 - a non-concentration-dependent adverse effect.
AU - Alkan, Y.
AU - Haefeli, W. E.
AU - Burhenne, J.
AU - Stein, J.
AU - Yaniv, I.
AU - Shalit, I.
PY - 2004
Y1 - 2004
N2 - A 15-year-old patient with acute lymphoblastic leukemia and Fusarium infection was treated with voriconazole. She developed asymptomatic bradycardia, QT interval prolongation, and nonsustained, polymorphic ventricular tachycardia, which recurred upon rechallenge with the drug. Voriconazole levels and metabolism were within expected normal values. This non-concentration-dependent, voriconazole-associated ventricular tachycardia mandates cardiac rhythm monitoring during voriconazole treatment.
AB - A 15-year-old patient with acute lymphoblastic leukemia and Fusarium infection was treated with voriconazole. She developed asymptomatic bradycardia, QT interval prolongation, and nonsustained, polymorphic ventricular tachycardia, which recurred upon rechallenge with the drug. Voriconazole levels and metabolism were within expected normal values. This non-concentration-dependent, voriconazole-associated ventricular tachycardia mandates cardiac rhythm monitoring during voriconazole treatment.
UR - http://www.scopus.com/inward/record.url?scp=21844457312&partnerID=8YFLogxK
U2 - 10.1086/423275
DO - 10.1086/423275
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AN - SCOPUS:21844457312
SN - 1058-4838
VL - 39
SP - e49-52
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 6
ER -
