TY - JOUR
T1 - Von Willebrand factor and mitral valve prolapse
AU - Froom, P.
AU - Margulis, T.
AU - Grenadier, E.
AU - Palant, A.
AU - David, M.
AU - Aghai, E.
PY - 1988
Y1 - 1988
N2 - The levels of von Willebrand factor (vWF:Ag) were measured in 27 patients with mitral valve prolapse (MVP) and compared to 27 age matched controls. Decreased levels of vWF:Ag (<80%) were found in 59% (16/27) of those with MVP compared to only 7% (2/27) of the controls (p < 0.001). Mean vWF:Ag levels were also significantly lower in those with MVP (68 ± 30% versus 100 ± 23%, p < 0.001). In those with MVP and congestive heart failure secondary to ruptured chordae tendineae, however, the mean level of vWF:Ag was not significantly different from control values (95 ± 32). There was an increased incidence of recurrent nose bleeds in those with MVP and low levels of vWF:Ag. We conclude that there is a relationship between MVP and low levels of vWF:Ag which may explain the increased incidence of epistaxis in such patients. Increased release of vWF:Ag in those with MVP and concomitant congestive heart failure may account for the normal levels found in this subgroup.
AB - The levels of von Willebrand factor (vWF:Ag) were measured in 27 patients with mitral valve prolapse (MVP) and compared to 27 age matched controls. Decreased levels of vWF:Ag (<80%) were found in 59% (16/27) of those with MVP compared to only 7% (2/27) of the controls (p < 0.001). Mean vWF:Ag levels were also significantly lower in those with MVP (68 ± 30% versus 100 ± 23%, p < 0.001). In those with MVP and congestive heart failure secondary to ruptured chordae tendineae, however, the mean level of vWF:Ag was not significantly different from control values (95 ± 32). There was an increased incidence of recurrent nose bleeds in those with MVP and low levels of vWF:Ag. We conclude that there is a relationship between MVP and low levels of vWF:Ag which may explain the increased incidence of epistaxis in such patients. Increased release of vWF:Ag in those with MVP and concomitant congestive heart failure may account for the normal levels found in this subgroup.
UR - http://www.scopus.com/inward/record.url?scp=0023787365&partnerID=8YFLogxK
U2 - 10.1055/s-0038-1647035
DO - 10.1055/s-0038-1647035
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AN - SCOPUS:0023787365
SN - 0340-6245
VL - 60
SP - 230
EP - 231
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
IS - 2
ER -