TY - GEN
T1 - Voltage-gated potassium channel as a facilitator of exocytosis
AU - Feinshreiber, Lori
AU - Singer-Lahat, Dafna
AU - Ashery, Uri
AU - Lotan, Ilana
PY - 2009/1
Y1 - 2009/1
N2 - Voltage-gated ion channels are well characterized for their function in excitability signals. Accumulating studies, however, have established an ion-independent function for the major classes of ion channels in cellular signaling. During the last few years we established a novel role for Kv2.1, a voltage-gated potassium (Kv) channel, classically known for its role of repolarizing the membrane potential, in facilitation of exocytosis. Kv2.1 induces facilitation of depolarization-induced release through its direct interaction with syntaxin, a protein component of the exocytotic machinery, independently of the potassium ion flow through the channel's pore. Here, we review our recent studies, further characterize the phenomena (using chromaffin cells and carbon fiber amperometry), and suggest plausible mechanisms that can underlie this facilitation of release.
AB - Voltage-gated ion channels are well characterized for their function in excitability signals. Accumulating studies, however, have established an ion-independent function for the major classes of ion channels in cellular signaling. During the last few years we established a novel role for Kv2.1, a voltage-gated potassium (Kv) channel, classically known for its role of repolarizing the membrane potential, in facilitation of exocytosis. Kv2.1 induces facilitation of depolarization-induced release through its direct interaction with syntaxin, a protein component of the exocytotic machinery, independently of the potassium ion flow through the channel's pore. Here, we review our recent studies, further characterize the phenomena (using chromaffin cells and carbon fiber amperometry), and suggest plausible mechanisms that can underlie this facilitation of release.
KW - Amperometry
KW - Chromaffin cells
KW - Exocytosis
KW - Kv2.1 channel
KW - Large dense-core vesicles release
KW - PC12 cells
KW - Pore-independent function
KW - Syntaxin
UR - http://www.scopus.com/inward/record.url?scp=58549113187&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2008.03997.x
DO - 10.1111/j.1749-6632.2008.03997.x
M3 - ???researchoutput.researchoutputtypes.contributiontobookanthology.conference???
C2 - 19161379
AN - SCOPUS:58549113187
SN - 9781573317351
T3 - Annals of the New York Academy of Sciences
SP - 87
EP - 92
BT - Mechanisms of Exocytosis
PB - Blackwell Publishing Inc.
ER -