Vitamin E Intake Is Associated with Lower Brain Volume in Haptoglobin 1-1 Elderly with Type 2 Diabetes

Abigail Livny, Michal Schnaider Beeri, Anthony Heymann, Erin Moshier, Yuval Berman, Mary Mamistalov, Danit Rivka Shahar, Galia Tsarfaty, Derek Leroith, Rachel Preiss, Laili Soleimani, Jeremy M. Silverman, Barbara B. Bendlin, Andrew Levy, Ramit Ravona-Springer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Backgrounds: The efficacy of vitamin E in prevention of diabetes-related complications differs by Haptoglobin (Hp) genotype. Objective: To examine the role of Hp genotype in the relationship of vitamin E intake with brain volume in cognitively normal elderly patients with type 2 diabetes. Methods: Brain volumes for the superior, middle, and inferior frontal gyri and for the middle temporal gyrus were generated from structural T1 MRI in 181 study participants (Hp 1-1: n = 24, Hp 2-1: n = 77, Hp 2-2: n = 80). Daily vitamin E intake was assessed using the Food Frequency Questionnaire. Analyses of covariance, controlling for demographic and cardiovascular variables was used to evaluate whether the association of daily vitamin E intake with brain volume was modified by Hp genotype. Results: Average age was 70.8 (SD = 4.2) with 40% females, and mean Mini-Mental State Examination score of 28.17 (SD = 1.90). A significant interaction was found between vitamin E intake and Hp genotype in inferior frontal gyrus' volume; p = 0.0108. For every 1 microgram increase in vitamin E intake, the volume of the inferior frontal gyrus decreased by 0.955% for Hp 1-1 (p = 0.0348), increased by 0.429% for Hp 2-1 (p = 0.0457), and by 0.077% for Hp 2-2 (p = 0.6318). There were no significant interactions between vitamin E intake and Hp genotype for the middle (p = 0.6011) and superior (p = 0.2025) frontal gyri or for the middle temporal gyrus (p = 0.503). Conclusions: The effect of dietary vitamin E on the brain may differ by Hp genotype. Studies examining the impact of vitamin E on brain-related outcomes should consider Hp genotype.

Original languageEnglish
Pages (from-to)649-658
Number of pages10
JournalJournal of Alzheimer's Disease
Issue number2
StatePublished - 2020


FundersFunder number
NIRG-11-205083 Alzheimer’s Association
National Institute on AgingR01 AG034087, P50AG005138
American Federation for Aging Research


    • Brain volume
    • Vitamin E
    • diabetes
    • haptoglobin genotype


    Dive into the research topics of 'Vitamin E Intake Is Associated with Lower Brain Volume in Haptoglobin 1-1 Elderly with Type 2 Diabetes'. Together they form a unique fingerprint.

    Cite this