Vitamin D and rheumatoid arthritis: An ongoing mystery

Nicola L. Bragazzi, Abdulla Watad, Shana G. Neumann, Michael Simon, Stav B. Brown, Arsalan Abu Much, Adam Harari, Shmuel Tiosano, Howard Amital, Yehuda Shoenfeld

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of review In recent years, there has been a growing interest in the value of vitamin D and its effects on autoimmunity. The aim of this review is to summarize the current knowledge on the association between vitamin D and rheumatoid arthritis (RA) in terms of prevalence, disease activity, clinical expression, serology and gene polymorphisms of vitamin D receptors. Recent findings Studies have shown contrasting findings concerning the association between vitamin D levels and RA. Vitamin D seems to have immunomodulatory properties. Therefore, low vitamin D levels could contribute to increased immune activation. However, the potential role of vitamin D supplementation in preventing RA manifestation and its beneficial role as a component of RA treatment remain controversial. The relationship between RA susceptibility and vitamin D polymorphisms is also unclear. Summary Despite advancements synthesized by some recent meta-analyses, the relationship between vitamin D and RA requires further evaluation. Further research is needed to confirm the relationship between RA susceptibility and vitamin D polymorphisms and to determine whether vitamin D plays a role in preventing the manifestation of RA. Finally, additional studies are required to determine the impact and optimal amount of vitamin D supplementation in the treatment of RA patients.

Original languageEnglish
Pages (from-to)378-388
Number of pages11
JournalCurrent Opinion in Rheumatology
Volume29
Issue number4
DOIs
StatePublished - 1 Jul 2017

Keywords

  • Vitamin D
  • autoimmunity
  • gene polymorphism
  • immunomodulation
  • rheumatoid arthritis

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