Vitamin D and autoimmune diseases

Shir Azrielant, Yehuda Shoenfeld

Research output: Contribution to journalReview articlepeer-review


Vitamin D and its deficiency are becoming a subject of great interest in recent years. In addition to the well-known role of Vitamin D in maintaining bone health, evidence from recent years are accumulating in favor of its importance in the functioning of the immune system. The association between Vitamin D deficiency and autoimmune diseases has been supported by epidemiological studies, demonstrating higher prevalence of Vitamin D deficiency among autoimmune patients, in comparison to the general population. Vitamin D was also associated to various autoimmune diseases in both molecular and interventional studies; among the associated diseases are: systemic lupus erythematosus, type 1 diabetes mellitus, multiple sclerosis and others. In this review, relevant literature on the association between autoimmunity and Vitamin D deficiency will be reviewed and discussed, as well as a summary of important recommendations for Vitamin D supplementations in autoimmune patients.

Original languageEnglish
Pages (from-to)219-222
Number of pages4
JournalIndian Journal of Rheumatology
Issue number4
StatePublished - Dec 2017


  • Autoimmunity
  • Vitamin D
  • multiple sclerosis
  • systemic lupus erythematosus
  • type 1 diabetes mellitus


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