Vitamin A levels are comparable between children with newly diagnosed coeliac disease and non-coeliac controls

Yael Weintraub, Amir Ben-Tov, Gad Dotan, Anat Yerushalmy-Feler, Dror Weiner, Dina Levy, Ronit Lubetzky, Shlomi Cohen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Aim: Nutritional deficiencies associated with coeliac disease include iron, folic acid and fat-soluble vitamins. This study compared the prevalence and degree of vitamin A deficiency among newly diagnosed coeliac disease patients to controls in a developed country. Methods: This prospective cohort study included all children evaluated by gastroscopy at Dana-Dwek Children's Hospital, Israel, between September 2014 and February 2017. Vitamin A, haemoglobin, C-reactive protein (CRP), ferritin, tissue transglutaminase, immunoglobulin A and vitamin D levels were measured. Results: Of the 113 children (69% females), 47 were diagnosed with coeliac disease whereas the others were the controls (mean age of 8.2 ± 3.8 years and 12.4 ± 3.5 years, respectively). There was no group difference in vitamin A, vitamin D or CRP levels. Among coeliac children, two had true vitamin A deficiency compared with three controls, while 18 coeliac children had subclinical vitamin A deficiency compared with 25 controls (p > 0.05). Conclusion: Paediatric coeliac disease was not associated with increased prevalence of vitamin A deficiency. Children evaluated for gastrointestinal complaints in a developed country were found to have an unexpectedly high prevalence of subclinical vitamin A deficiency. Further prevalence and causality assessments of vitamin A deficiency in developed countries are needed.

Original languageEnglish
Pages (from-to)2095-2099
Number of pages5
JournalActa Paediatrica, International Journal of Paediatrics
Issue number11
StatePublished - 1 Nov 2019


  • Coeliac disease
  • Developed country
  • Gastrointestinal complaints
  • Retinol
  • Vitamin A deficiency


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