TY - JOUR
T1 - Visual function following photodynamic therapy for central serous chorioretinopathy
T2 - A comparison of automated macular microperimetry versus best-corrected visual acuity
AU - Ehrlich, Rita
AU - Mawer, Nick P.
AU - Mody, Christopher H.
AU - Brand, Christopher S.
AU - Squirrell, David
PY - 2012/2
Y1 - 2012/2
N2 - Background: The study compares the change in best-corrected visual acuity with the change in central retinal sensitivity before treatment and 6months after treatment with photodynamic therapy in patients with symptomatic central serous chorio retinopathy. Design: Prospective, single-centre, interventional case series. Participants: Eleven consecutive patients with previously untreated central serous chorio retinopathy. Methods: Patients had microperimetry and best-corrected visual acuity recorded before and 6months after treatment with photodynamic therapy. Refracted best-corrected visual acuity was assessed at 2m and adjusted to give the number of letters read at 1m. Threshold microperimetry was performed by presenting a Goldman III stimulus to 29 points over the central 12° around fixation. Significant visual improvement at 6months was defined as a best-corrected visual acuity ≥10 letters or, microperimetry change in mean retinal sensitivity ≥2 decibels (dB). Main Outcome Measures: Improvement in best-corrected visual acuity compared with microperimetry following photodynamic therapy treatment in patients with central serous chorio retinopathy. Results: All patients reported a subjective improvement in vision and had complete resolution of subretinal fluid at 6months. Two patients had a significant improvement in best-corrected visual acuity (mean±SD +4.2±5.8 letters), compared with all 11 patients who recorded a significant improvement in mean retinal sensitivity (mean±SD 4.6±1.9dB) (P<0.001). Conclusions: These data suggest that compared with microperimetry, best-corrected visual acuity is underestimating the effectiveness of photodynamic therapy in the treatment of central serous chorio retinopathy.
AB - Background: The study compares the change in best-corrected visual acuity with the change in central retinal sensitivity before treatment and 6months after treatment with photodynamic therapy in patients with symptomatic central serous chorio retinopathy. Design: Prospective, single-centre, interventional case series. Participants: Eleven consecutive patients with previously untreated central serous chorio retinopathy. Methods: Patients had microperimetry and best-corrected visual acuity recorded before and 6months after treatment with photodynamic therapy. Refracted best-corrected visual acuity was assessed at 2m and adjusted to give the number of letters read at 1m. Threshold microperimetry was performed by presenting a Goldman III stimulus to 29 points over the central 12° around fixation. Significant visual improvement at 6months was defined as a best-corrected visual acuity ≥10 letters or, microperimetry change in mean retinal sensitivity ≥2 decibels (dB). Main Outcome Measures: Improvement in best-corrected visual acuity compared with microperimetry following photodynamic therapy treatment in patients with central serous chorio retinopathy. Results: All patients reported a subjective improvement in vision and had complete resolution of subretinal fluid at 6months. Two patients had a significant improvement in best-corrected visual acuity (mean±SD +4.2±5.8 letters), compared with all 11 patients who recorded a significant improvement in mean retinal sensitivity (mean±SD 4.6±1.9dB) (P<0.001). Conclusions: These data suggest that compared with microperimetry, best-corrected visual acuity is underestimating the effectiveness of photodynamic therapy in the treatment of central serous chorio retinopathy.
KW - Central serous chorio retinopathy
KW - Microperimetry
KW - Photodynamic therapy
UR - http://www.scopus.com/inward/record.url?scp=84856634204&partnerID=8YFLogxK
U2 - 10.1111/j.1442-9071.2011.02654.x
DO - 10.1111/j.1442-9071.2011.02654.x
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C2 - 21745265
AN - SCOPUS:84856634204
VL - 40
SP - e32-e39
JO - Clinical and Experimental Ophthalmology
JF - Clinical and Experimental Ophthalmology
SN - 1442-6404
IS - 1
ER -