TY - JOUR
T1 - Visual field disturbances in epileptic patients treated with vigabatrin (sevril)
AU - Gross-Tsur, Varda
AU - Lahat, Eli
AU - Banin, Eyal
AU - Shahar, Eli
AU - Shalev, Ruth
PY - 2002
Y1 - 2002
N2 - Vigabatrin, one of the newer anti-epileptic drugs (AED), whose effect is mediated via elevated levels of brain GABA, has proved to be effective in drug resistant partial seizures and infantile spasms. Recently, visual field constriction was found in up to 30% of adults, whereas information for the pediatric age group is sparse. We examined 24 visually asymptomatic children, ages 3.5-18 years, treated for 3.01.6 years at doses of 25-90 mg/kg. These children underwent an ophthalmologic examination, visual evoked potentials, electroretinogram and when possible, perimetry. Over half of the children had at least one abnormal test and 11/17, who were able to undergo perimetric studies, had symmetrical, nasal visual field constriction. In view of the gravity and prevalence of visual field constriction, use of the AED vigabatrin should be weighed against its clinical benefits.
AB - Vigabatrin, one of the newer anti-epileptic drugs (AED), whose effect is mediated via elevated levels of brain GABA, has proved to be effective in drug resistant partial seizures and infantile spasms. Recently, visual field constriction was found in up to 30% of adults, whereas information for the pediatric age group is sparse. We examined 24 visually asymptomatic children, ages 3.5-18 years, treated for 3.01.6 years at doses of 25-90 mg/kg. These children underwent an ophthalmologic examination, visual evoked potentials, electroretinogram and when possible, perimetry. Over half of the children had at least one abnormal test and 11/17, who were able to undergo perimetric studies, had symmetrical, nasal visual field constriction. In view of the gravity and prevalence of visual field constriction, use of the AED vigabatrin should be weighed against its clinical benefits.
KW - Anti-epileptic drug
KW - ERG-VEP
KW - Epilepsy
KW - Vigabatrin
KW - Visual field constriction
UR - http://www.scopus.com/inward/record.url?scp=0036073395&partnerID=8YFLogxK
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AN - SCOPUS:0036073395
SN - 0017-7768
VL - 141
SP - 247-249+315
JO - Harefuah
JF - Harefuah
IS - 3
ER -