TY - JOUR
T1 - Virulence factors of septicemic Escherichia coli strains
AU - Mokady, Daphna
AU - Gophna, Uri
AU - Ron, Eliora Z.
N1 - Funding Information:
This work was supported by the Manja and Morris Leigh Chair for Biophysics and Biotechnology, the Israel Center for Emerging Diseases and the European Community project COLIRISK.
PY - 2005/10/5
Y1 - 2005/10/5
N2 - Extraintestinal pathogenic Escherichia coli strains (ExPEC) are the cause of a diverse spectrum of invasive human and animal infections, often leading to septicemia. This review deals with the virulence genes of septicemic ExPEC strains. We discuss the meaning of a virulence gene and survey the genomic, genetic and physiological studies on these strains. Apparently, there are a few virulence factors, which are conserved in the septicemic strains, implying that they are essential for the infection. For the other virulence-related genes a high level of diversity is observed, demonstrating that all stages of the infection can be mediated by a number of alternative virulence factors. The variable profile of virulence genes in septicemic E. coli strains, as well as a prevalence of mobility-related sequences point out the existence of a "mix and match" combinatorial system.
AB - Extraintestinal pathogenic Escherichia coli strains (ExPEC) are the cause of a diverse spectrum of invasive human and animal infections, often leading to septicemia. This review deals with the virulence genes of septicemic ExPEC strains. We discuss the meaning of a virulence gene and survey the genomic, genetic and physiological studies on these strains. Apparently, there are a few virulence factors, which are conserved in the septicemic strains, implying that they are essential for the infection. For the other virulence-related genes a high level of diversity is observed, demonstrating that all stages of the infection can be mediated by a number of alternative virulence factors. The variable profile of virulence genes in septicemic E. coli strains, as well as a prevalence of mobility-related sequences point out the existence of a "mix and match" combinatorial system.
UR - http://www.scopus.com/inward/record.url?scp=24044493520&partnerID=8YFLogxK
U2 - 10.1016/j.ijmm.2005.07.007
DO - 10.1016/j.ijmm.2005.07.007
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AN - SCOPUS:24044493520
SN - 1438-4221
VL - 295
SP - 455
EP - 462
JO - International Journal of Medical Microbiology
JF - International Journal of Medical Microbiology
IS - 6-7
ER -
