@article{860e92ded6f64f89b6d80bf846bbc9b5,
title = "Virulence and the heat shock response",
abstract = "The major adaptive response to elevation in temperature is the heat shock response that involves the induction of many proteins - called heat shock proteins. These include chaperones, proteases, alternative sigma factors and other regulatory and structural proteins. The heat shock response is also turned on by other stress conditions, such as oxidative stress or pH changes. Bacterial entry into the host organism involves a significant environmental change, which is expected to induce the heat shock response. Indeed, some of the heat shock proteins are themselves virulence factors while others affect pathogenesis indirectly, by increasing bacterial resistance to host defenses or regulating virulence genes. The cross talk between heat shock and virulence genes is discussed.",
keywords = "Chaperones, Heat shock, Pathogenesis, Proteases, Stress response, Virulence",
author = "Uri Gophna and Ron, {Eliora Z.}",
note = "Funding Information: Acknowledgements. This work was supported, in part, by the German Israeli Science Foundation (GIF), by the Manja and Morris Leigh Chair for Biophysics and Biotechnology, and by the Center of Emerging Diseases, Israel. U. Gophna was partially supported by the Wolf doctoral fellowship.",
year = "2003",
month = feb,
doi = "10.1078/1438-4221-00230",
language = "אנגלית",
volume = "292",
pages = "453--461",
journal = "International Journal of Medical Microbiology",
issn = "1438-4221",
publisher = "Elsevier GmbH",
number = "7-8",
}