Keyphrases
Pathogenic Variants
100%
Molecular Dynamics Simulation
100%
Functional Significance
100%
Sodium Channel
100%
Patch-clamp Analysis
100%
Na +
60%
Bioinformatics Tools
40%
Clinical Phenotype
40%
Gain-of-function
40%
Loss Function
40%
Pore Diameter
40%
Further Development
20%
Pathogenicity
20%
3D Structure
20%
Autism
20%
Schrdinger
20%
Targeted Treatment
20%
Mutant Protein
20%
Channel Opening
20%
Homology Modeling
20%
Voltage-gated Sodium Channel
20%
Early Onset
20%
Partial Loss
20%
Disease Phenotype
20%
Dravet Syndrome
20%
Amino Acid Motifs
20%
Sodium Ion
20%
Modeling Time
20%
Drug-resistant Epilepsy
20%
Neuronal Depolarization
20%
Ion Pore
20%
Biochemistry, Genetics and Molecular Biology
Patch Clamp
100%
Sodium Channel
100%
Wild Type
75%
Pore Size
50%
Bioinformatics
50%
Electric Potential
25%
Homology Modeling
25%
Protein Motif
25%
Neuronal Depolarization
25%
Pharmacology, Toxicology and Pharmaceutical Science
Sodium Ion
100%
Sodium Channel
100%
Amino Acid
25%
Voltage Gated Sodium Channel
25%
Pathogenicity
25%
Drug Resistant Epilepsy
25%
Severe Myoclonic Epilepsy in Infancy
25%
Diseases
25%
Neuroscience
Patch Clamp
100%
Sodium Channel
100%
Voltage Gated Sodium Channel
25%
Dravet Syndrome
25%
Protein Motif
25%
Neuronal Depolarization
25%
Autism
25%