Virtual karyotyping reveals greater chromosomal stability in neural cells derived by transdifferentiation than those from stem cells

Uri Weissbein, Uri Ben-David, Nissim Benvenisty

Research output: Contribution to journalArticlepeer-review

Abstract

Neural cells can be derived either from pluripotent or adult stem cells via differentiation or by transdifferentiation from other cell types with the aid of tissue regulators. We compared the chromosomal stability of over 500 neural cell samples from human and mouse with virtual karyotyping (e-karyotyping). We detected notable genomic instability in cells derived from pluripotent or adult stem cells, but surprisingly, transdifferentiated cells seemed more chromosomally stable, except if they were reprogrammed using pluripotency factors.

Original languageEnglish
Pages (from-to)687-691
Number of pages5
JournalCell Stem Cell
Volume15
Issue number6
DOIs
StatePublished - 4 Dec 2014
Externally publishedYes

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