ViroidDB: A database of viroids and viroid-like circular RNAs

Benjamin D. Lee*, Uri Neri, Caleb J. Oh, Peter Simmonds, Eugene V. Koonin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We introduce ViroidDB, a value-added database that attempts to collect all known viroid and viroid-like circular RNA sequences into a single resource. Spanning about 10 000 unique sequences, ViroidDB includes viroids, retroviroid-like elements, small circular satellite RNAs, ribozyviruses, and retrozymes. Each sequence's secondary structure, ribozyme content, and cluster membership are predicted via a custom pipeline optimized for handling circular RNAs. The data can be explored via a purpose-built user interface that features visualizations, multiple sequence alignments, and a portal for downloading bulk data. Users can browse the data by sequence type, taxon, or typo-tolerant search of metadata fields. The database is freely accessible at

Original languageEnglish
Pages (from-to)D432-D438
JournalNucleic Acids Research
Issue numberD1
StatePublished - 7 Jan 2022


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