Viral hepatitis with extreme hyperbilirubinemia, massive hemolysis and encephalopathy in a patient with a new G6PD variant

Y. Sidi, D. Aderka, F. Brok-Simoni, D. Benjamin, B. Ramot, J. Pinkhas

Research output: Contribution to journalArticlepeer-review

Abstract

Extreme hyperbilirubinemia, massive hemolysis and hepatic encephalopathy were reported in a G6PD-deficient patient with viral hepatitis. Investigation of the G6PD properties revealed that this patient's enzyme represented a hitherto undescribed variant (Bnei Brak), characterized by heat stability and a unique triphasic pH-related enzyme activity curve. It is possible that the marked hemolytic process in this patient was enhanced by a further decrease in the activity of the already deficient enzyme during acidosis.

Original languageEnglish
Pages (from-to)130-133
Number of pages4
JournalIsrael Journal of Medical Sciences
Volume16
Issue number2
StatePublished - 1980
Externally publishedYes

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