@article{101d02ef3c4b430ab9be6b779becf07b,
title = "VIP-mRNA is increased in hypertensive rats",
abstract = "Vasoactive intestinal peptide (VIP) is a potent vasodilator. We therefore set out to investigate VIP-gene expression in spontaneous hypertensive rats. By quantitative in situ hybridization histochemistry as well as by RNA blot hybridization experiments we discovered a significant increase in VIP transcripts in the brains of those hypertensive rats. We suggest that the increase in VIP-gene expression may play a compensatory role in these rats where otherwise the rise in blood pressure may have had a much more adverse effect.",
keywords = "Hypertensive rat, In situ hybridization, Messenger RNA, Vasoactive intestinal peptide",
author = "Rina Avidor and Raya Eilam and Rafael Malach and Illana Gozes",
note = "Funding Information: 1 Biegon, A, and Israeli, M., Quantitative autoradiographic analysis of the effects of electroconvulsive shock on serotonin-2 receptors in males and females, J. Neurochem., 48 (1987) 1386--1391. 2 Bloch, B., Popovici, T., Le Guellec, D., Normand, E., Chau-hart, S., Guitanny, A.E and Bohlen, P., In situ hybridization histochemistry for the analysis of gene expression in die endocrine and central nervous system tissues: a 3-year experi-ence, J. Neurosci. Res., 16 (1986) 183-200. 3 Bunag, R.D., Eferakeya, A.E. and Landon, D.S., Enhance-ment of hypothalamic pressor responses in spontaneously hy-pertensive rats, Am. J. Physiol., 228 (1975) 217. 4 Card, J.P., Fitzpatrick-McElligot, S., Gozes, I. and Baldino, F. Jr., Localization of vasopressin-, vasoactive intestinal polypep-tide-, peptide histidine isoleucine-and ~omatostatin-mRNA in rat suprachiasmatic nucleus, Cell Tissue Res., 252 (1988) 309-315. 5 Card, J.P. and Moore, R.Y., Ventral lateral geniculate nucleus efferents to the rat suprachiasmatic nucleus exhibit avian pancreatic polypeptide-like immunoreactivity, J. Comp. Neu-roL, 206 (1982) 390-396. 6 Eckenstein, F. and Baughman, R.W., Two types of cholinergic innervation in cortex, one co-localized with vasoactive intestinal polypeptide, Nature (Lond.) 309 (1984) 153-155. 7 Fahrenkrug, J. and Emson, P., Vasoactive intestinal polypep. tide: functional aspects, Br. Med. Bull., 38 (1982) 265-270. 8 Gozes, I., Avidor, R., Biegon, A. and Baldino, E Jr., Lactation elevates vasoactive intestinal peptide messenger ribonucleic acid in rat suprachiasmatic nucleus, Endocrinology, 124 (1989) 181-186. 9 Gozes, I. and Shani, Y., Hypothalamic vasoactive intestinal peptide messenger ribonucleic acid is increased in lactating rats, Endocrinology, 110 (1986) 2497-2501. 10 Gozes, I., Shani, Y. and Rostene, W.H., Developmental expression of the VIP-gene in brain and intestine, Mol. Brain Res., 2 (1987) 137-148. 11 Huang, M. and Rorstad, O.P., Effects of vasoactive intestinal polypeptide, monoamines, prostaglandins and 2-chloroadeno-sine on adnylate cyclase in rat cerebral microvessels, J. Neuro-chem., 40 (1983) 719-726. 12 Itoh, N., Obata, K.-i., Yanaihara, N. and Okamoto, H., Human preprovasoactive intestinal polypeptide contains a novel PHI- We thank Prof. Anat Biegon for the teaching and the use of the image analysis system. Supported partly by the United States Israel Binational Science Foundation. I.G. is the incumbent of the Samuel O. Freedman career Development chair.",
year = "1989",
month = dec,
day = "4",
doi = "10.1016/0006-8993(89)91679-X",
language = "אנגלית",
volume = "503",
pages = "304--307",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",
}