VIP-mRNA is increased in hypertensive rats

Rina Avidor, Raya Eilam, Rafael Malach, Illana Gozes*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Vasoactive intestinal peptide (VIP) is a potent vasodilator. We therefore set out to investigate VIP-gene expression in spontaneous hypertensive rats. By quantitative in situ hybridization histochemistry as well as by RNA blot hybridization experiments we discovered a significant increase in VIP transcripts in the brains of those hypertensive rats. We suggest that the increase in VIP-gene expression may play a compensatory role in these rats where otherwise the rise in blood pressure may have had a much more adverse effect.

Original languageEnglish
Pages (from-to)304-307
Number of pages4
JournalBrain Research
Volume503
Issue number2
DOIs
StatePublished - 4 Dec 1989
Externally publishedYes

Funding

FundersFunder number
United States - Israel Binational Science Foundation

    Keywords

    • Hypertensive rat
    • In situ hybridization
    • Messenger RNA
    • Vasoactive intestinal peptide

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