TY - JOUR
T1 - Very Low-Frequency Heart Rate Variability Wave Amplitude and Sympathetic Stimulation—Characterization and Modeling
AU - Leor-Librach, Ron Joseph
AU - Eliash, Sarah
AU - Kaplinsky, Elieser
AU - Bobrovsky, Ben Zion
PY - 2003/7
Y1 - 2003/7
N2 - The purpose of this study was to assess the relationship between very low-frequency heart rate variability (LFHR) wave amplitude and the degree of sympathetic stimulation. We developed a computerized system for the controlled increase of heart rate (HR) by isoproterenol (ISP), with which we obtained a series of stabilized HR levels in conscious freely moving rats. We found that LFHR amplitude rises gradually as a function of the average HR for each level until it reaches a point where additional increases in average HR are associated with gradual decrease in LFHR amplitude. We successfully built and fitted a model of LFHR amplitude to the experimental results. The fact that our model fits the experimental data well may suggest a possible relationship between our LFHR amplitude findings and the basic physiologic properties of the HR-ISP system inherent in our model.
AB - The purpose of this study was to assess the relationship between very low-frequency heart rate variability (LFHR) wave amplitude and the degree of sympathetic stimulation. We developed a computerized system for the controlled increase of heart rate (HR) by isoproterenol (ISP), with which we obtained a series of stabilized HR levels in conscious freely moving rats. We found that LFHR amplitude rises gradually as a function of the average HR for each level until it reaches a point where additional increases in average HR are associated with gradual decrease in LFHR amplitude. We successfully built and fitted a model of LFHR amplitude to the experimental results. The fact that our model fits the experimental data well may suggest a possible relationship between our LFHR amplitude findings and the basic physiologic properties of the HR-ISP system inherent in our model.
KW - Heart rate control
KW - heart rate variability
KW - isopro-terenol
KW - physiological modeling
UR - http://www.scopus.com/inward/record.url?scp=0041662217&partnerID=8YFLogxK
U2 - 10.1109/TBME.2003.813547
DO - 10.1109/TBME.2003.813547
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AN - SCOPUS:0041662217
SN - 0018-9294
VL - 50
SP - 797
EP - 803
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 7
ER -