Very Low-Frequency Heart Rate Variability Wave Amplitude and Sympathetic Stimulation—Characterization and Modeling

Ron Joseph Leor-Librach, Sarah Eliash, Elieser Kaplinsky, Ben Zion Bobrovsky

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The purpose of this study was to assess the relationship between very low-frequency heart rate variability (LFHR) wave amplitude and the degree of sympathetic stimulation. We developed a computerized system for the controlled increase of heart rate (HR) by isoproterenol (ISP), with which we obtained a series of stabilized HR levels in conscious freely moving rats. We found that LFHR amplitude rises gradually as a function of the average HR for each level until it reaches a point where additional increases in average HR are associated with gradual decrease in LFHR amplitude. We successfully built and fitted a model of LFHR amplitude to the experimental results. The fact that our model fits the experimental data well may suggest a possible relationship between our LFHR amplitude findings and the basic physiologic properties of the HR-ISP system inherent in our model.

Original languageEnglish
Pages (from-to)797-803
Number of pages7
JournalIEEE Transactions on Biomedical Engineering
Volume50
Issue number7
DOIs
StatePublished - Jul 2003

Keywords

  • Heart rate control
  • heart rate variability
  • isopro-terenol
  • physiological modeling

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