Verapamil is not an antidepressant in patients resistant to tricyclic antidepressants

S. Adlersberg, P. Toren, R. Mester, M. Rehavi, P. Skolnick, A. Weizman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The effects of a calcium channel blocker (verapamil, 160-320 mg/day for 4 weeks) were studied in seven unipolar major-depressed patients resistant to treatment with tricyclic antidepressants. This regimen of verapamil did not alter either the Hamilton rating scales for depression and anxiety or the Beck depression inventory score in these patients. Thus, verapamil appears devoid of antidepressant properties in patients resistant to tricyclic antidepressants.

Original languageEnglish
Pages (from-to)294-297
Number of pages4
JournalClinical Neuropharmacology
Issue number3
StatePublished - 1994
Externally publishedYes


  • Anxiety
  • Calcium channel blockers
  • Depression
  • Tricyclic antidepressants
  • Verapamil


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