Ventricular response to dobutamine stress cardiac magnetic resonance imaging is associated with adverse outcome during 8-year follow-up in patients with repaired tetralogy of fallot

Eva van den Bosch, Judith A.A.E. Cuypers, Saskia E. Luijnenburg, Nienke Duppen, Eric Boersma, Ricardo P.J. Budde, Gabriel P. Krestin, Nico A. Blom, Hans M.P.J. Breur, Miranda M. Snoeren, Jolien W. Roos-Hesselink, Livia Kapusta, Willem A. Helbing

Research output: Contribution to journalArticlepeer-review

Abstract

Aims The aim of this study was to evaluate the possible value of dobutamine stress cardiac magnetic resonance imaging (CMR) to predict adverse outcome in Tetralogy of Fallot (TOF) patients. Methods In previous prospective multicentre studies, TOF patients underwent low-dose dobutamine stress CMR (7.5 mg/kg/ and results min). Subsequently, during regular-care patient follow-up, patients were assessed for reaching the composite endpoint (cardiac death, arrhythmia-related hospitalization, or cardioversion/ablation, VO2 max <_65% of predicted). A normal stress response was defined as a decrease in end-systolic volume (ESV) and increase in ejection fraction. The relative parameter change during stress was calculated as relative parameter change = [(parameterstress - parameterrest)/parameterrest] * 100. The predictive value of dobutamine stress CMR for the composite endpoint was determined using time-to-event analyses (Kaplan-Meier) and Cox proportional hazard analysis. We studied 100 patients [67 (67%) male, median age at baseline CMR 17.8 years (interquartile range 13.5-34.0), age at TOF repair 0.9 years (0.6-2.1)]. After a median follow-up of 8.6 years (6.7-14.1), 10 patients reached the composite endpoint. An abnormal stress response (30% vs. 4.4%, P = 0.021) was more frequently observed in composite endpoint patients. Also in endpoint patients, the relative decrease in right ventricular ESV decreased less during stress compared with the patients without an endpoint (-17 ± 15 vs. -26 ± 13 %, P = 0.045). Multivariable analyses identified an abnormal stress response (hazard ratio 10.4; 95% confidence interval 2.5-43.7; P = 0.001) as predictor for the composite endpoint. Conclusion An abnormal ventricular response to dobutamine stress is associated with adverse outcome in patients with repaired TOF.

Original languageEnglish
Pages (from-to)1039-1046
Number of pages8
JournalEuropean Heart Journal Cardiovascular Imaging
Volume21
Issue number9
DOIs
StatePublished - 1 Sep 2020

Keywords

  • Cardiac magnetic resonance imaging
  • Congenital heart disease
  • Dobutamine
  • Outcome
  • Stress imaging
  • Tetralogy of Fallot

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