Ventricular myosin of the shrew Crocidura russula, correlation with contractile properties

G. Kessler-Icekson; H. Schlesinger; J. J. Leger; J. Leger; Y. Braverman; O. Binah

doi:10.1016/0022-2828(88)90583-4

Ventricular myosin of the shrew Crocidura russula, correlation with contractile properties

G. Kessler-Icekson^*, H. Schlesinger, J. J. Leger, J. Leger, Y. Braverman, O. Binah

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The present study demonstrates that in the shrew ventricular muscle the speed of tension development and relaxation, as well as twitch duration, are much shorter than in the guinea-pig. It also shows that ventricular myosin of the shrrw has a high Ca²⁺-activated ATPase activity and that it is composed of α-type heavy chains. Namely, the native molecule is a V₁ variety of myosin. These findings advance our knowledge on an as yet uncharacterized mammalian heart and further demonstrate the correlation between mechanical properties and myosin type in heart muscle.

Original language	English
Pages (from-to)	1069-1073
Number of pages	5
Journal	Journal of Molecular and Cellular Cardiology
Volume	20
Issue number	11
DOIs	https://doi.org/10.1016/0022-2828(88)90583-4
State	Published - Dec 1988
Externally published	Yes

Keywords

Guinea-pig
Isometric twitch characteristics
Myosin ATPase
Myosin heavy chains
Shrew

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10.1016/0022-2828(88)90583-4

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title = "Ventricular myosin of the shrew Crocidura russula, correlation with contractile properties",

abstract = "The present study demonstrates that in the shrew ventricular muscle the speed of tension development and relaxation, as well as twitch duration, are much shorter than in the guinea-pig. It also shows that ventricular myosin of the shrrw has a high Ca2+-activated ATPase activity and that it is composed of α-type heavy chains. Namely, the native molecule is a V1 variety of myosin. These findings advance our knowledge on an as yet uncharacterized mammalian heart and further demonstrate the correlation between mechanical properties and myosin type in heart muscle.",

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author = "G. Kessler-Icekson and H. Schlesinger and Leger, {J. J.} and J. Leger and Y. Braverman and O. Binah",

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AU - Schlesinger, H.

AU - Leger, J. J.

AU - Leger, J.

AU - Braverman, Y.

AU - Binah, O.

PY - 1988/12

Y1 - 1988/12

N2 - The present study demonstrates that in the shrew ventricular muscle the speed of tension development and relaxation, as well as twitch duration, are much shorter than in the guinea-pig. It also shows that ventricular myosin of the shrrw has a high Ca2+-activated ATPase activity and that it is composed of α-type heavy chains. Namely, the native molecule is a V1 variety of myosin. These findings advance our knowledge on an as yet uncharacterized mammalian heart and further demonstrate the correlation between mechanical properties and myosin type in heart muscle.

AB - The present study demonstrates that in the shrew ventricular muscle the speed of tension development and relaxation, as well as twitch duration, are much shorter than in the guinea-pig. It also shows that ventricular myosin of the shrrw has a high Ca2+-activated ATPase activity and that it is composed of α-type heavy chains. Namely, the native molecule is a V1 variety of myosin. These findings advance our knowledge on an as yet uncharacterized mammalian heart and further demonstrate the correlation between mechanical properties and myosin type in heart muscle.

KW - Guinea-pig

KW - Isometric twitch characteristics

KW - Myosin ATPase

KW - Myosin heavy chains

KW - Shrew

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IS - 11

ER -

Ventricular myosin of the shrew Crocidura russula, correlation with contractile properties

Abstract

Keywords

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