Ventral hypothalamic lesions block the consumption of morphine in rats

Zalman Amit; Michael E. Corcoran; Shimon Amir; Gideon Urca

doi:10.1016/0024-3205(73)90071-4

Ventral hypothalamic lesions block the consumption of morphine in rats

Zalman Amit^*, Michael E. Corcoran, Shimon Amir, Gideon Urca

^*Corresponding author for this work

Physiology Pharmacology

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Two stage lesions of the ventral aspects of the lateral hypothalamus blocked the drinking of morphine solutions by rats even when these solutions were presented as the only source of fluids. Lesions of more dorsal portions of the lateral hypothalamus did not have a significant effect on drinking of morphine solutions. An explanation in terms of the involvement of reinforcement mechanisms in morphine consumption and its relation to the integrity of catecholamine pathways is discussed.

Original language	English
Pages (from-to)	805-816
Number of pages	12
Journal	Life Sciences
Volume	13
Issue number	7
DOIs	https://doi.org/10.1016/0024-3205(73)90071-4
State	Published - 1 Oct 1973

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title = "Ventral hypothalamic lesions block the consumption of morphine in rats",

abstract = "Two stage lesions of the ventral aspects of the lateral hypothalamus blocked the drinking of morphine solutions by rats even when these solutions were presented as the only source of fluids. Lesions of more dorsal portions of the lateral hypothalamus did not have a significant effect on drinking of morphine solutions. An explanation in terms of the involvement of reinforcement mechanisms in morphine consumption and its relation to the integrity of catecholamine pathways is discussed.",

author = "Zalman Amit and Corcoran, {Michael E.} and Shimon Amir and Gideon Urca",

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AB - Two stage lesions of the ventral aspects of the lateral hypothalamus blocked the drinking of morphine solutions by rats even when these solutions were presented as the only source of fluids. Lesions of more dorsal portions of the lateral hypothalamus did not have a significant effect on drinking of morphine solutions. An explanation in terms of the involvement of reinforcement mechanisms in morphine consumption and its relation to the integrity of catecholamine pathways is discussed.

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Ventral hypothalamic lesions block the consumption of morphine in rats

Abstract

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