TY - JOUR
T1 - Velocardiofacial Syndrome
AU - Gothelf, Doron
N1 - Funding Information:
This work was funded in part by the National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award and the Basil O'Connor Starter Scholar Research Award of the March of Dimes (Grant No. 5-FY06-590).
PY - 2007/7
Y1 - 2007/7
N2 - Velocardiofacial syndrome (VCFS) is the most common known microdeletion in humans. It is also the most common known genetic risk factor for schizophrenia. The aim of this article is to describe the clinical characteristics of the syndrome, with emphasis on the myriad psychiatric disorders and abnormal behaviors from a developmental perspective. In addition, the possible pathways that lead to the psychotic symptoms and cognitive deficits are discussed. Guidelines are suggested to alert clinicians to the possibility of the presence of VCFS, and the cumulative clinical experience and limited research on psychiatric treatments for VCFS are presented. There is an urgent need to conduct treatment trials in this high-risk population.
AB - Velocardiofacial syndrome (VCFS) is the most common known microdeletion in humans. It is also the most common known genetic risk factor for schizophrenia. The aim of this article is to describe the clinical characteristics of the syndrome, with emphasis on the myriad psychiatric disorders and abnormal behaviors from a developmental perspective. In addition, the possible pathways that lead to the psychotic symptoms and cognitive deficits are discussed. Guidelines are suggested to alert clinicians to the possibility of the presence of VCFS, and the cumulative clinical experience and limited research on psychiatric treatments for VCFS are presented. There is an urgent need to conduct treatment trials in this high-risk population.
UR - http://www.scopus.com/inward/record.url?scp=34249941507&partnerID=8YFLogxK
U2 - 10.1016/j.chc.2007.03.005
DO - 10.1016/j.chc.2007.03.005
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C2 - 17562586
AN - SCOPUS:34249941507
VL - 16
SP - 677
EP - 693
JO - Child and Adolescent Psychiatric Clinics of North America
JF - Child and Adolescent Psychiatric Clinics of North America
SN - 1056-4993
IS - 3
ER -
