Vasoconstrictor effects of sarafotoxins in rabbit aorta: Structure-function relationships

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Abstract

The sarafotoxins SRTX-a, b and c from the venom of the snake Atractaspis engaddensis are 21-amino acid peptides that affect the cardiovascular system. They are strong vasoconstrictors, the potency of which may be in correlation with their primary structure: SRTX-a, which differs from SRTX-b in a single amino acid residue (Asn instead of Tyr), shows about half of its maximal vasoconstriction, while SRTX-c, which differs in 3 additional residues is a very weak vasoconstrictor and, at high doses, shows vasodilatory effects. Sequential application of the three isotoxins result in a summated response.

Original languageEnglish
Pages (from-to)371-376
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume162
Issue number1
DOIs
StatePublished - 14 Jul 1989

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