Vascular elasticity of systemic lupus erythematosus patients is associated with steroids and hydroxychloroquine treatment

Amir Tanay*, Eyal Leibovitz, Angela Frayman, Reuven Zimlichman, Dov Gavish

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

47 Scopus citations

Abstract

We studied the large and small artery elasticity (AE) and systemic vascular resistance (SVR) of systemic lupus erythematosus (SLE) patients according to treatment profile. Forty-one SLE patients (90% female, mean age 48.7 ± 2.4 years) were compared to 96 healthy controls. The large and small AE and the SVR were derived from radial artery waveforms (model CR-2000, HDI Inc.). Patients were categorized into groups according to treatment: steroid (12), hydroxychloroquine (HCQ) (9), steroid+HCQ (16), and no-steroidsno-HCQ (4). The steroid group had reduced large AE and increased SVR as compared to the HCQ group (8.3 mmHg·mL·10 and 18.4 dyne·sec·10 -3 versus 13.7 and 14.4, respectively). Mean large AE and the SVR of the HCQ group was similar to that of the controls (11.8 mmHg·mL·10 and 14.5 dyne·sec·10-3, respectively). Mean large AE and SVR of the steroid+HCQ group were better than the steroid group (10.4 mmHg·mL·10 and 16.0 dyne·sec·10-3). Patients that received steroids had higher rates of hypertension (36%) and diabetes (11%) compared to rest of the patients (15% and 0%, respectively). Small AE, blood pressure, CRP, and SLEDAI were similar between the groups. Among SLE patients, steroid treatment was associated with the highest degree of vascular damage, and HCQ was associated with the lowest degree of vascular damage. It is possible that the steroids are responsible in part to the increased large-vessel manifestations observed in these patients, and that HCQ might have a protective effect on the vessel wall.

Original languageEnglish
Title of host publicationAutoimmunity, Part D
Subtitle of host publicationAutoimmune Disease, Annus Mirabilis
PublisherBlackwell Publishing Inc.
Pages24-34
Number of pages11
ISBN (Print)157331708X, 9781573317085
DOIs
StatePublished - Jun 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1108
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Arterial elasticity
  • Atherosclerosis
  • Hydroxychloroquine
  • SLE
  • Steroids

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