Variation in the HTR1A and HTR2A genes and social adjustment in depressed patients

Niki Antypa; Raffaella Calati; Daniel Souery; Silvia Pellegrini; Othman Sentissi; Daniela Amital; Ulrike Moser; Stuart Montgomery; Siegfried Kasper; Joseph Zohar; Diana De Ronchi; Julien Mendlewicz; Alessandro Serretti

doi:10.1016/j.jad.2013.02.036

Variation in the HTR1A and HTR2A genes and social adjustment in depressed patients

Niki Antypa, Raffaella Calati, Daniel Souery, Silvia Pellegrini, Othman Sentissi, Daniela Amital, Ulrike Moser, Stuart Montgomery, Siegfried Kasper, Joseph Zohar, Diana De Ronchi, Julien Mendlewicz, Alessandro Serretti^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Background: Social adjustment is impaired in depressed patients. The difficulty to adjust to social circumstances has been hypothesized to be one of the causes of depression, as well as a consequence of the disorder. Genetic variation in the serotonin transporter gene has been previously associated with social adjustment levels in patients with mood disorders. Methods: We investigated whether variations on the HTR1A (rs6295) and HTR2A (rs7997012) genes were associated with levels of social adjustment using the Social Adjustment Scale in two samples of depressed patients (total n=156). Results: Patients carrying the GG genotype of the HTR2A-rs7997012 showed better social adjustment in areas of work and family unit bonding. Limitations: These findings did not survive correction for multiple testing and should be interpreted with caution. Conclusion: Our finding is in line with previous observations that have associated the G allele of the HTR2A-rs7997012 with higher rate of antidepressant response. The HTR2A-rs7997012 is worthy of further investigation in studies examining factors that are related to depression course and outcome.

Original language	English
Pages (from-to)	649-652
Number of pages	4
Journal	Journal of Affective Disorders
Volume	150
Issue number	2
DOIs	https://doi.org/10.1016/j.jad.2013.02.036
State	Published - 5 Sep 2013
Externally published	Yes

Funding

Funders	Funder number
Netherlands Organization for Scientific Research
Marie Curie
Fonds De La Recherche Scientifique - FNRS	3.4.530.07F
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Ministero dell’Istruzione, dell’Università e della Ricerca	446-11-004, 2008XWR4SB
H. Lundbeck A/S

Keywords

Depression
Serotonin genes
Social adjustment

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10.1016/j.jad.2013.02.036

Cite this

@article{53868aaebaca420b84c5f6078ab5bf0b,

title = "Variation in the HTR1A and HTR2A genes and social adjustment in depressed patients",

abstract = "Background: Social adjustment is impaired in depressed patients. The difficulty to adjust to social circumstances has been hypothesized to be one of the causes of depression, as well as a consequence of the disorder. Genetic variation in the serotonin transporter gene has been previously associated with social adjustment levels in patients with mood disorders. Methods: We investigated whether variations on the HTR1A (rs6295) and HTR2A (rs7997012) genes were associated with levels of social adjustment using the Social Adjustment Scale in two samples of depressed patients (total n=156). Results: Patients carrying the GG genotype of the HTR2A-rs7997012 showed better social adjustment in areas of work and family unit bonding. Limitations: These findings did not survive correction for multiple testing and should be interpreted with caution. Conclusion: Our finding is in line with previous observations that have associated the G allele of the HTR2A-rs7997012 with higher rate of antidepressant response. The HTR2A-rs7997012 is worthy of further investigation in studies examining factors that are related to depression course and outcome.",

keywords = "Depression, Serotonin genes, Social adjustment",

author = "Niki Antypa and Raffaella Calati and Daniel Souery and Silvia Pellegrini and Othman Sentissi and Daniela Amital and Ulrike Moser and Stuart Montgomery and Siegfried Kasper and Joseph Zohar and {De Ronchi}, Diana and Julien Mendlewicz and Alessandro Serretti",

note = "Funding Information: The study was sponsored by Lundbeck A/S and the Belgian National Fund for Scientific Research (FNRS; 3.4.530.07F) by means of an unrestricted grant for the Group for the Study of Resistant Depression (GSRD). This research was also sponsored in part by MIUR (2008XWR4SB). The work of Niki Antypa is supported by the “Rubicon” Grant (#446-11-004), awarded by the Netherlands Organization for Scientific Research (NWO) and the Marie Curie Cofund Action. The sponsors had no role in the study design, analysis and writing of the paper. ",

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doi = "10.1016/j.jad.2013.02.036",

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T1 - Variation in the HTR1A and HTR2A genes and social adjustment in depressed patients

AU - Antypa, Niki

AU - Calati, Raffaella

AU - Souery, Daniel

AU - Pellegrini, Silvia

AU - Sentissi, Othman

AU - Amital, Daniela

AU - Moser, Ulrike

AU - Montgomery, Stuart

AU - Kasper, Siegfried

AU - Zohar, Joseph

AU - De Ronchi, Diana

AU - Mendlewicz, Julien

AU - Serretti, Alessandro

N1 - Funding Information: The study was sponsored by Lundbeck A/S and the Belgian National Fund for Scientific Research (FNRS; 3.4.530.07F) by means of an unrestricted grant for the Group for the Study of Resistant Depression (GSRD). This research was also sponsored in part by MIUR (2008XWR4SB). The work of Niki Antypa is supported by the “Rubicon” Grant (#446-11-004), awarded by the Netherlands Organization for Scientific Research (NWO) and the Marie Curie Cofund Action. The sponsors had no role in the study design, analysis and writing of the paper.

PY - 2013/9/5

Y1 - 2013/9/5

N2 - Background: Social adjustment is impaired in depressed patients. The difficulty to adjust to social circumstances has been hypothesized to be one of the causes of depression, as well as a consequence of the disorder. Genetic variation in the serotonin transporter gene has been previously associated with social adjustment levels in patients with mood disorders. Methods: We investigated whether variations on the HTR1A (rs6295) and HTR2A (rs7997012) genes were associated with levels of social adjustment using the Social Adjustment Scale in two samples of depressed patients (total n=156). Results: Patients carrying the GG genotype of the HTR2A-rs7997012 showed better social adjustment in areas of work and family unit bonding. Limitations: These findings did not survive correction for multiple testing and should be interpreted with caution. Conclusion: Our finding is in line with previous observations that have associated the G allele of the HTR2A-rs7997012 with higher rate of antidepressant response. The HTR2A-rs7997012 is worthy of further investigation in studies examining factors that are related to depression course and outcome.

AB - Background: Social adjustment is impaired in depressed patients. The difficulty to adjust to social circumstances has been hypothesized to be one of the causes of depression, as well as a consequence of the disorder. Genetic variation in the serotonin transporter gene has been previously associated with social adjustment levels in patients with mood disorders. Methods: We investigated whether variations on the HTR1A (rs6295) and HTR2A (rs7997012) genes were associated with levels of social adjustment using the Social Adjustment Scale in two samples of depressed patients (total n=156). Results: Patients carrying the GG genotype of the HTR2A-rs7997012 showed better social adjustment in areas of work and family unit bonding. Limitations: These findings did not survive correction for multiple testing and should be interpreted with caution. Conclusion: Our finding is in line with previous observations that have associated the G allele of the HTR2A-rs7997012 with higher rate of antidepressant response. The HTR2A-rs7997012 is worthy of further investigation in studies examining factors that are related to depression course and outcome.

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KW - Serotonin genes

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JO - Journal of Affective Disorders

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ER -

Variation in the HTR1A and HTR2A genes and social adjustment in depressed patients

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