Variation in serum levels of the soluble TNF receptors among healthy individuals

D. Aderka, H. Engelmann, Y. Shemer-Avni, V. Hornik, A. Galil, B. Sarov, D. Wallach*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

143 Scopus citations


Soluble forms of the two receptors for tumor necrosis factor (TNF) are present in human sera at concentrations that increase greatly in various disease states as well as varying among healthy individuals. Measurements of the soluble TNF receptor (sTNF-R) concentrations in healthy individuals at time lapses of 3 months (17 individuals) or 1 year (51 individuals) showed a significant correlation between the first and the second measurements from each individual, implying that individual differences are stable. Since the sTNF-Rs are believed to function as physiological attenuators of TNF activity, these steady individual differences may contribute to differences in the severity of the harmful effects of TNF in disease states.

Original languageEnglish
Pages (from-to)157-159
Number of pages3
JournalLymphokine and Cytokine Research
Issue number3
StatePublished - 1992
Externally publishedYes


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