@article{7eb7db2ce4a64f1b9a9340561a4b1e8a,
title = "Variance-components QTL linkage analysis of selected and non-normal samples: Conditioning on trait values",
abstract = "Standard variance-components quantitative trait loci (QTL) linkage analysis can produce an elevated rate of type 1 errors when applied to selected samples and non-normal data. Here we describe an adjustment of the log-likelihood function based on conditioning on trait values. This leads to a likelihood ratio test that is valid in selected samples and non-normal data, and equal in power to alternative methods for analyzing selected samples that require knowledge of the ascertainment procedure or the trait values of non-selected individuals. (C) 2000 Wiley-Liss, Inc.",
keywords = "Conditioning, Linkage, Normality, Quantitative trait loci (QTL), Selection",
author = "Sham, {Pak Chung} and Zhao, {Jing Hua} and Cherny, {Stacey S.} and Hewitt, {John K.}",
year = "2000",
doi = "10.1002/1098-2272(2000)19:1+<::AID-GEPI4>3.0.CO;2-S",
language = "אנגלית",
volume = "19",
pages = "S22--S28",
journal = "Genetic Epidemiology",
issn = "0741-0395",
publisher = "Wiley-Liss Inc.",
}