Vandetanib (ZD6474): An orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis

Roy S. Herbst*, John V. Heymach, Michael S. O'Reilly, Amir Onn, Anderson J. Ryan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Vandetanib (ZD6474; ZACTIMA™, AstraZeneca) is a once-daily, orally available agent with potential for use in a number of solid tumor types. Vandetanib targets key signaling pathways in cancer by inhibiting VEGFR-dependent tumor angiogenesis, and EGFR- and RET-dependent tumor cell proliferation and survival. Phase I studies showed vandetanib to be generally well tolerated at doses of ≤ 300 mg/day, with a pharmacokinetic profile that supports once-daily oral administration. Phase II evaluation of vandetanib in patients with advanced refractory NSCLC has demonstrated improvements in progression-free survival both as monotherapy (versus gefitinib) and in combination with docetaxel (versus docetaxel alone). These positive outcomes have led to the initiation of Phase III trials of vandetanib in advanced NSCLC. Clinical development is also ongoing in other tumor types and encouraging evidence of antitumor activity has been reported in patients with metastatic hereditary medullary thyroid cancer.

Original languageEnglish
Pages (from-to)239-249
Number of pages11
JournalExpert Opinion on Investigational Drugs
Volume16
Issue number2
DOIs
StatePublished - Feb 2007
Externally publishedYes

Keywords

  • Angiogenesis inhibitor
  • Medullary thyroid cancer
  • Non-small cell lung cancer
  • Tyrosine kinase inhibitor
  • Vandetanib
  • ZD6474

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