Vancomycin and ceftazidime bioactivities persist for at least 2 weeks in the lumen in ports: Simplifying treatment of port-associated bloodstream infections by using the antibiotic lock technique

Y. Haimi-Cohen, N. Husain, J. Meenan, G. Karayalcin, M. Lehrer, L. G. Rubin

Research output: Contribution to journalArticlepeer-review

Abstract

The residual antibiotic concentration of vancomycin (2 mg/ml)- or ceftazidime (2 mg/ml)-heparin solutions instilled in ports in pediatric hematology-oncology patients 1 to 34 days earlier was measured. Antibiotic concentrations of ≥100 μg of either antibiotic per ml persisted for at least 21 days. For treatment of lumenal port infections, antibiotic-heparin dwell times of ≥2 weeks may be appropriate.

Original languageEnglish
Pages (from-to)1565-1567
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume45
Issue number5
DOIs
StatePublished - 2001
Externally publishedYes

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