TY - JOUR
T1 - Valproic acid-induced eosinophilic pleural effusion
T2 - A case report and review of the literature
AU - Kamenetsky, Zvi
AU - Da'As, Nael
AU - Esayag, Yaacov
AU - Kleinman, Yosef
AU - Samuels, Noah
PY - 2012/1
Y1 - 2012/1
N2 - We present a case of eosinophilic pleural effusion due to valproic acid (VPA), a rare adverse event that has been reported previously. A 30-year-old male patient presented with respiratory symptoms and right-sided pleuritic pain, within days of initiation of VPA treatment for a generalized seizure. Chest radiography revealed a moderate-sized right-sided pleural effusion, which was an exudate with a pH of 7.54 and 48% eosinophils. Symptoms resolved soon after discontinuation of the drug, as did the effusion in a repeat radiograph 3 weeks later. The likelihood that VPA was the cause of the effusion is examined.
AB - We present a case of eosinophilic pleural effusion due to valproic acid (VPA), a rare adverse event that has been reported previously. A 30-year-old male patient presented with respiratory symptoms and right-sided pleuritic pain, within days of initiation of VPA treatment for a generalized seizure. Chest radiography revealed a moderate-sized right-sided pleural effusion, which was an exudate with a pH of 7.54 and 48% eosinophils. Symptoms resolved soon after discontinuation of the drug, as did the effusion in a repeat radiograph 3 weeks later. The likelihood that VPA was the cause of the effusion is examined.
KW - Valproic acid
KW - adverse drug reaction
KW - eosinophilic pleural effusion
KW - toxicity
UR - http://www.scopus.com/inward/record.url?scp=84855464253&partnerID=8YFLogxK
U2 - 10.1097/NRL.0b013e31823d7a6d
DO - 10.1097/NRL.0b013e31823d7a6d
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C2 - 22217614
AN - SCOPUS:84855464253
SN - 1074-7931
VL - 18
SP - 39
EP - 40
JO - Neurologist
JF - Neurologist
IS - 1
ER -